CAJ | 학술논문

目的应用斑点追踪技术评价心肌梗死大鼠不同时间段左室心肌形变及功能变化规律及特点.方法选取同年龄健康成年SD大鼠20只,结扎大鼠前降支近端建立心肌梗死模型.将心功能符合要求且心肌梗死后仍存活的15只心肌梗死大鼠按照不同观察时间点分为术前对照、心肌梗死1d、4周和8周共4组.分别测量乳头肌短轴水平径向应变率(radial strain rate,SRrad)和圆周应变率(circumferential strain rate,SRcir)的收缩期峰值(SRrad-S和SRcir-S),舒张早期峰值应变率(SRrad-E和SRcir-E),舒张晚期峰值应变率(SRrad-A和SRcir-A).测量左室二维超声指标.结果心肌梗死1d组SRrad-S、SRradE、SRcir-S及SRcir-E在前壁和侧壁较心肌梗死前相应节段降低.心肌梗死4周组SRrad、SRcir在各节段较心肌梗死前各相应节段均降低.心肌梗死8周组左室心肌各节段SRrad、SRcir与心肌梗死4周组比较差异无统计学意义.结论斑点追踪技术可以量化评价心肌梗死大鼠重构心肌的形变特点,有望为研究缺血性心脏疾病的病理变化特点提供新的技术支持.
목적 응용반점추종기술평개심기경사대서불동시간단좌실심기형변급공능변화규률급특점.방법 선취동년령건강성년SD대서20지,결찰대서전강지근단건립심기경사모형.장심공능부합요구차심기경사후잉존활적15지심기경사대서안조불동관찰시간점분위술전대조、심기경사1d、4주화8주공4조.분별측량유두기단축수평경향응변솔(radial strain rate,SRrad)화원주응변솔(circumferential strain rate,SRcir)적수축기봉치(SRrad-S화SRcir-S),서장조기봉치응변솔(SRrad-E화SRcir-E),서장만기봉치응변솔(SRrad-A화SRcir-A).측량좌실이유초성지표.결과 심기경사1d조SRrad-S、SRradE、SRcir-S급SRcir-E재전벽화측벽교심기경사전상응절단강저.심기경사4주조SRrad、SRcir재각절단교심기경사전각상응절단균강저.심기경사8주조좌실심기각절단SRrad、SRcir여심기경사4주조비교차이무통계학의의.결론 반점추종기술가이양화평개심기경사대서중구심기적형변특점,유망위연구결혈성심장질병적병리변화특점제공신적기술지지.
Objective To evaluate left ventricular (LV) remodeling and function after acute myocardial infarction (MI) in rats using speckle tracking imaging (STI). Methods The left anterior descending coronary was ligated to induce MI in twenty normal rats. One day after creation of MI, fifty survivals based on the diagnostic criteria of MI were divided into 4 groups as follows:pre-infarction, 1 day,4weeks,and 8 weeks after MI. Echocardiography was performed to evaluate the changes of left ventricularfunction in rats. M-mode and two-dimensional cross-sectional echocardiography data were acquired at the papillary muscle level and digitally stored for further analysis. Circumferential strain rate(SRcir) and radial strain rate(SRrad) indexes were measured by STI software for each animal. Results One day after MI,indexes of SRcir and SRrad in anterior and lateral segments were significantly decreased (P ＜0.01, for both). Four weeks after MI,compared with baseline,SRrad and SRcir were decreased in all segments ( P ＜0.01). Eight weeks after MI, however, SRrad and SRcir showed no significant difference compared with 4weeks group. Conclusions STI can correctly identify LV dysfunction in rats and can be used for serial assessment of cardiac remodeling in rats models.