CAJ | 학술논문

为观察胎脑组织移植对双侧额叶皮层损伤大鼠学习、记忆功能的影响,对大鼠模型行胎脑组织移植.学习、记忆再现测验在Y型迷宫中进行.大鼠学习和记忆成绩以测验时达到10次电击均为正确反应时所需的电击次数表示.结果显示,胎脑组织移植能显著减少达到上述标准所需的电击次数,且移植3个月较移植10天的动物达到上次标准所需的训练次数减少更明显.组织学检查揭示,移植的神经组织不仅存活,分化良好,而且与宿主脑之间有部分融合.结果表明,胎脑组织移植能促进双侧额叶皮层损伤大鼠学习、记忆功能的恢复,并提示移植3～6个月后移植物与宿主脑之间可形成部分纤维连接.
위관찰태뇌조직이식대쌍측액협피층손상대서학습、기억공능적영향,대대서모형행태뇌조직이식.학습、기억재현측험재Y형미궁중진행.대서학습화기억성적이측험시체도10차전격균위정학반응시소수적전격차수표시.결과현시,태뇌조직이식능현저감소체도상술표준소수적전격차수,차이식3개월교이식10천적동물체도상차표준소수적훈련차수감소경명현.조직학검사게시,이식적신경조직불부존활,분화량호,이차여숙주뇌지간유부분융합.결과표명,태뇌조직이식능촉진쌍측액협피층손상대서학습、기억공능적회복,병제시이식3～6개월후이식물여숙주뇌지간가형성부분섬유련접.
Effects of transplantation of fetal brain on learning and memory of discrimination performance were observed in the rats with damage to bilateral cortexes.The rats were placed on an electrified grid in a Y-maze and learned to run into the light arm(safe area).The criterion of learning or memory retrieval was met after the animals had correctly made 10 of 10 consecutive choices.The results showed that implanting fetal brain tissue into the damaged frontal cortexes of the rats had caused a significant decrease in the number of trials needed to meet the criterion.The decrease in the number of trials needed to meet the criterion in the rats which began behavioral training 3 mouths after transplantation was more obvious compared to that in the rats which began the training 10 days following transplantation.Histological examination revealed that implanted brain tissue with well-differentiation survived and that there were merges betweeh the graft and host brain in some areas 3 or 6 months after transplantation.Our results showed that the trans-plantation of embryonic brain tissue could promote recovery of learning and memory retrieval of visual discrimination in the rats with damage of bilateral frontal cortexes and that connections between the brain tissue implants and host brain tissue could develop.