中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
3期
21-22
,共2页
序贯疗法%幽门螺杆菌%十二指肠溃疡
序貫療法%幽門螺桿菌%十二指腸潰瘍
서관요법%유문라간균%십이지장궤양
Sequential therapy%Helicobacter pylori%Duodenal ulcer
目的 评估序贯疗法治疗幽门螺杆菌(Hp)阳性十二指肠溃疡的疗效与安全性.方法 选取70例经胃镜检查确诊且1个月内14C尿素呼气试验阳性的十二指肠溃疡患者,随机分为两组:治疗组前5 d给予雷贝拉唑、阿莫西林,后 5 d给予雷贝拉唑、替硝唑、克拉霉素治疗;对照组予雷贝拉唑加阿莫西林、克拉霉素治疗7 d.两组均继续予雷贝拉唑治疗3周,记录用药后患者症状缓解情况.疗程结束1个月后复查胃镜并行14C尿素呼气试验检测.结果 治疗组Hp根除率为94.1%,对照组根除率为77.8%,两组比较差异有统计学意义(P<0.05);治疗组症状缓解率为94.1%,溃疡治愈率为91.2%,对照组症状缓解率为88.9%,溃疡治愈率为86.1%,但两组间差异无统计学意义(P>0.05).两组不良反应发生率比较差异无统计学意义(P>0.05).结论 序贯疗法治疗Hp阳性十二指肠溃疡具有疗效高、耐受性和依从性好等优点.
目的 評估序貫療法治療幽門螺桿菌(Hp)暘性十二指腸潰瘍的療效與安全性.方法 選取70例經胃鏡檢查確診且1箇月內14C尿素呼氣試驗暘性的十二指腸潰瘍患者,隨機分為兩組:治療組前5 d給予雷貝拉唑、阿莫西林,後 5 d給予雷貝拉唑、替硝唑、剋拉黴素治療;對照組予雷貝拉唑加阿莫西林、剋拉黴素治療7 d.兩組均繼續予雷貝拉唑治療3週,記錄用藥後患者癥狀緩解情況.療程結束1箇月後複查胃鏡併行14C尿素呼氣試驗檢測.結果 治療組Hp根除率為94.1%,對照組根除率為77.8%,兩組比較差異有統計學意義(P<0.05);治療組癥狀緩解率為94.1%,潰瘍治愈率為91.2%,對照組癥狀緩解率為88.9%,潰瘍治愈率為86.1%,但兩組間差異無統計學意義(P>0.05).兩組不良反應髮生率比較差異無統計學意義(P>0.05).結論 序貫療法治療Hp暘性十二指腸潰瘍具有療效高、耐受性和依從性好等優點.
목적 평고서관요법치료유문라간균(Hp)양성십이지장궤양적료효여안전성.방법 선취70례경위경검사학진차1개월내14C뇨소호기시험양성적십이지장궤양환자,수궤분위량조:치료조전5 d급여뢰패랍서、아막서림,후 5 d급여뢰패랍서、체초서、극랍매소치료;대조조여뢰패랍서가아막서림、극랍매소치료7 d.량조균계속여뢰패랍서치료3주,기록용약후환자증상완해정황.료정결속1개월후복사위경병행14C뇨소호기시험검측.결과 치료조Hp근제솔위94.1%,대조조근제솔위77.8%,량조비교차이유통계학의의(P<0.05);치료조증상완해솔위94.1%,궤양치유솔위91.2%,대조조증상완해솔위88.9%,궤양치유솔위86.1%,단량조간차이무통계학의의(P>0.05).량조불량반응발생솔비교차이무통계학의의(P>0.05).결론 서관요법치료Hp양성십이지장궤양구유료효고、내수성화의종성호등우점.
Objective To evaluate the efficacy and safety of sequential therapy in the treatment of duodenal ulcer complicated with Helicobacter pylori(Hp). Methods Seventy patients with Hp positive duodenal ulcer were randomly divided into two groups. The treatment group were treated with rabeprazole,amoxillin at first five days; rabeprazole, clarithromycin and tinidazole at the second five days. The control group were treated with rabeprazole,amoxillin and clarithromycin for seven days. Two groups were treated with rabeprazole for 3 weeks sequentially. Gastroscopy and Hp test were performed in the fourth week after the end of the treatment. Results The Hp eradication rate was 94.1%in treatment group,while it was 77.8% in control group. There was significant difference between the two groups(P<0.05). The ulcer healing rate of treatment group was 91.2%, while it was 86.1% in control group.The symptomatic relief rate was 94.1% in treatment group, while it was 88.9% in control group. But there was no significant difference between the two groups(P>0.05). Conclusions Sequential therapy is more effective, well tolerated and with higher rate of eradication.
