国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2012年
10期
726-728
,共3页
肿瘤%糖酵解%治疗
腫瘤%糖酵解%治療
종류%당효해%치료
Neoplasms%Glycolysis%Therapies
肿瘤细胞即使在供氧充足的条件下仍存在糖酵解途径的异常激活与线粒体呼吸受抑,以满足恶性增殖的需要.这一代谢表型的转变与肿瘤细胞线粒体功能缺陷、微环境缺氧状态、糖酵解途径上游调控因子的异常激活密切相关.针对肿瘤细胞糖酵解通路及其上游调控因子的靶向治疗有望为肿瘤治疗提供新的策略.
腫瘤細胞即使在供氧充足的條件下仍存在糖酵解途徑的異常激活與線粒體呼吸受抑,以滿足噁性增殖的需要.這一代謝錶型的轉變與腫瘤細胞線粒體功能缺陷、微環境缺氧狀態、糖酵解途徑上遊調控因子的異常激活密切相關.針對腫瘤細胞糖酵解通路及其上遊調控因子的靶嚮治療有望為腫瘤治療提供新的策略.
종류세포즉사재공양충족적조건하잉존재당효해도경적이상격활여선립체호흡수억,이만족악성증식적수요.저일대사표형적전변여종류세포선립체공능결함、미배경결양상태、당효해도경상유조공인자적이상격활밀절상관.침대종류세포당효해통로급기상유조공인자적파향치료유망위종류치료제공신적책략.
Cancer cells display a decreased mitochondrial respiration along with an abnormal activation of glycolysis to satisfy the demand of the malignant growth even in the presence of oxygen.This phenomenon may be caused by mitochondrial dysfunction,hypoxia of microenvironment and the abnormal activation of upstream regulators of glycolysis pathway.Treatment targeted at the glycolysis pathway and its upstream regulators may provide a new therapeutic strategy of cancer.