CAJ | 학술논문

目的研究胶质瘤1p/19q联合缺失与患者性别、年龄、肿瘤部位及病理分型是否具有相关性.方法用荧光原位杂交法(Fluorescence in situ hybridization,FISH)对2009年1月至12月的138例胶质细胞瘤患者术后胶质瘤标本进行1P和19q缺失状态分析,男性80例,女性58例;年龄17～68岁,平均41.6岁.利用X2检验分析不同性别、年龄、肿瘤部位、病理类型的1p/19q联合缺失是否有差异.结果星形细胞肿瘤(22.2%)的1p/19q联合缺失率显著低于少枝胶质细胞肿瘤(81.3%)和少枝星形细胞肿瘤(55.8%)(P＜0.01),少枝胶质细胞肿瘤的1p/19q联合缺失率高于少枝星形细胞肿瘤(P＜0.05).额叶胶质瘤的1p/19q联合缺失率(61.8%)显著高于颢叶(31.8%)和岛叶(34.6%)(P＜0.05).1p/19q联合缺失与患者的性别、年龄无明显相关性.结论 1p/19q联合缺失主要与胶质瘤的病理类型和部位相关,与患者的年龄和性别无明显相关性.
목적 연구효질류1p/19q연합결실여환자성별、년령、종류부위급병리분형시부구유상관성.방법 용형광원위잡교법(Fluorescence in situ hybridization,FISH)대2009년1월지12월적138례효질세포류환자술후효질류표본진행1P화19q결실상태분석,남성80례,녀성58례;년령17～68세,평균41.6세.이용X2검험분석불동성별、년령、종류부위、병리류형적1p/19q연합결실시부유차이.결과 성형세포종류(22.2%)적1p/19q연합결실솔현저저우소지효질세포종류(81.3%)화소지성형세포종류(55.8%)(P＜0.01),소지효질세포종류적1p/19q연합결실솔고우소지성형세포종류(P＜0.05).액협효질류적1p/19q연합결실솔(61.8%)현저고우호협(31.8%)화도협(34.6%)(P＜0.05).1p/19q연합결실여환자적성별、년령무명현상관성.결론 1p/19q연합결실주요여효질류적병리류형화부위상관,여환자적년령화성별무명현상관성.
objectives To find possible factors correlated with combined loss of heterozygosity (LOH)of 1 P and 19q.Methods The status of 1 P and 19q of 138 glioma specimen from January 2009 to December 2009 was evaluated by Fluorescence in situ hybridization(FISH)method,and the frequencies of combining LOH of 1 p/19q were compared between different pathologies,brain sub-regions,genders and ages.Results The frequencies of combined LOH of 1P and 19q of oligodendroglial(81.3%)and oligoastrocytic tumors(55.8%)were significantly higher than that of agtrocytic tumor(22.2%)(P＜0.01),and the frequency of oligodendroglial tumor was significantly higher than that of oligoastrocytic tumor (P＜0.05).The frequency of combining LOH of 1P and 19q in frontal lobe(61.8%)was higer than that in temporal(31.8%)and insular lobes(34.6%)(P＜0.05).Conclusion Combining LOH of 1P and 19q has significant correlation with the pathologies and brain sub-regions.