中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINESE JOURNAL OF DIABETES
2005年
2期
90-92
,共3页
付方明%董砚虎%李利平%高维国%石海燕%丁明%马臻%南海荣%王丽华%王元善%顾丽娜%钱荣立
付方明%董硯虎%李利平%高維國%石海燕%丁明%馬臻%南海榮%王麗華%王元善%顧麗娜%錢榮立
부방명%동연호%리리평%고유국%석해연%정명%마진%남해영%왕려화%왕원선%고려나%전영립
糖调节受损%空腹血糖受损%糖耐量受损%胰岛素抵抗
糖調節受損%空腹血糖受損%糖耐量受損%胰島素牴抗
당조절수손%공복혈당수손%당내량수손%이도소저항
Impaired glucose regulation%Impaired fasting glucose% Impaired glucose tolerance% Insulin resistance
目的评价糖调节受损(IGR)人群胰岛素抵抗(IR)与胰岛β细胞功能状态. 方法 (1)从青岛地区流行病学调查资料中,选取正常糖耐量(NGT)者447例;IGR 277例,其中空腹血糖受损(IFG)142例;糖耐量受损(IGT)93例;IFG+IGT42例.(2)测身高、体重、腰围、血压及血脂,空腹与糖负荷后血糖、胰岛素.(3)评价IR及基础与糖负荷后早期胰岛素分泌功能. 结果 IGR人群的年龄、血压、体质指数(BMI)、腰围、腰臀比均明显高于NGT人群.而IGT组的年龄、甘油三酯高于IFG组.校正年龄、性别及BMI等因素后,IGR人群HOMA-IR增高 (P<0.05), IFG、IGT及IFG+IGT组间无差异;IFG与IFG+IGT组的HOMA-β明显低于NGT和IGT组(P<0.01); IGT组△I30/△G30低于NGT(P<0.05).Logistic回归分析显示,年龄、BMI、HOMA-IR及HOMA-β与IFG的发生密切相关(P<0.01),年龄、BMI、△I30/△G30则与IGT的发生相关(P<0.05). 结论 IGR人群存在IR,同时IFG基础状态下胰岛β细胞功能轻度受损,而IGT人群的早期胰岛素分泌反应减弱.
目的評價糖調節受損(IGR)人群胰島素牴抗(IR)與胰島β細胞功能狀態. 方法 (1)從青島地區流行病學調查資料中,選取正常糖耐量(NGT)者447例;IGR 277例,其中空腹血糖受損(IFG)142例;糖耐量受損(IGT)93例;IFG+IGT42例.(2)測身高、體重、腰圍、血壓及血脂,空腹與糖負荷後血糖、胰島素.(3)評價IR及基礎與糖負荷後早期胰島素分泌功能. 結果 IGR人群的年齡、血壓、體質指數(BMI)、腰圍、腰臀比均明顯高于NGT人群.而IGT組的年齡、甘油三酯高于IFG組.校正年齡、性彆及BMI等因素後,IGR人群HOMA-IR增高 (P<0.05), IFG、IGT及IFG+IGT組間無差異;IFG與IFG+IGT組的HOMA-β明顯低于NGT和IGT組(P<0.01); IGT組△I30/△G30低于NGT(P<0.05).Logistic迴歸分析顯示,年齡、BMI、HOMA-IR及HOMA-β與IFG的髮生密切相關(P<0.01),年齡、BMI、△I30/△G30則與IGT的髮生相關(P<0.05). 結論 IGR人群存在IR,同時IFG基礎狀態下胰島β細胞功能輕度受損,而IGT人群的早期胰島素分泌反應減弱.
목적평개당조절수손(IGR)인군이도소저항(IR)여이도β세포공능상태. 방법 (1)종청도지구류행병학조사자료중,선취정상당내량(NGT)자447례;IGR 277례,기중공복혈당수손(IFG)142례;당내량수손(IGT)93례;IFG+IGT42례.(2)측신고、체중、요위、혈압급혈지,공복여당부하후혈당、이도소.(3)평개IR급기출여당부하후조기이도소분비공능. 결과 IGR인군적년령、혈압、체질지수(BMI)、요위、요둔비균명현고우NGT인군.이IGT조적년령、감유삼지고우IFG조.교정년령、성별급BMI등인소후,IGR인군HOMA-IR증고 (P<0.05), IFG、IGT급IFG+IGT조간무차이;IFG여IFG+IGT조적HOMA-β명현저우NGT화IGT조(P<0.01); IGT조△I30/△G30저우NGT(P<0.05).Logistic회귀분석현시,년령、BMI、HOMA-IR급HOMA-β여IFG적발생밀절상관(P<0.01),년령、BMI、△I30/△G30칙여IGT적발생상관(P<0.05). 결론 IGR인군존재IR,동시IFG기출상태하이도β세포공능경도수손,이IGT인군적조기이도소분비반응감약.
Objective To investigate insulin resistance （IR）and dysfunction of islet β cell in 277 Chinese with impaired glucose regulation（IGR）. Methods 724 participants （256 males）in Qingdao were classified into four groups: normal glucose tolerance （NGT, n=447）, impaired fasting glucose （IFG, n=142）, impaired glucose tolerance （IGT, n=93）, combined IFG and IGT （IFG+IGT, n=42）. The levels of plasma glucose, lipids （TC, HDL-C, TG）and insulin were measured. HOMA-IR, HOMA-β and △I30/△G30 after OGTT were calculated. Multivariable logistic regression （MVLR）was used to analyze the factors related to IFG and IGT. Results The age, waist circumference, body mass index（BMI）, and blood pressure were more elevated in the groups of IFG, IGT and IFG plus IGT than those in NGT. Age and TG were higher in IGT than in IFG. After adjusting age, sex, （systolic） blood pressure and BMI, IGR had significantly increased HOMA-IR. However, there was no difference in those among IFG, IGT, and IFG+IGT. HOMA-β decreased significantly in groups of IFG（4.53±0.06） and IFG+IGT （4.38±0.10）than that in groups of NGT（5.10±0.04）and IGT（5.11±0.07）. Meanwhile, there was no difference in that between NGT and IGT. △I30/△G30 was lower in IGT（4.62±0.14） vs NGT, but was no difference among IFG（4.86±0.11）, IFG+IGT（4.70±0.22） and NGT（4.99±0.11）. Age, BMI, and IR were independent risk factors for IFG, and basic β cell function was protective factor for IFG. Age and BMI were independent risk factors, and early phase of insulin secretion was protective factor for IGT. Conclusion Both IR and insulin （secretion） deficiency （ISD）are present in IGR subjects. The IFG subjects have IR and ISD, but still maintain the early phase of insulin secretion. The IGT subjects have IR and defect of the early phase of insulin secretion, but still maintain basic β-cell function.
