CAJ | 학술논문

目的观察罗格列酮对2型糖尿病(T2DM)合并高血压(EH)患者的降血糖、降血压疗效以及改善胰岛素抵抗和尿微量白蛋白的作用.方法 68例T2DM合并EH的患者随机分为治疗组和对照组,治疗组35例在服用二甲双胍和缬沙坦的基础上加用罗格列酮4 mg/d.对照组不加罗格列酮,疗程均为16周.比较治疗前后两组患者的空腹血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(HbA1c)、收缩压(SBP)、舒张压(DBP)、尿白蛋白排泄率(UAE)、空腹胰岛素(FINS)、胰岛素抵抗指数(IRI),同时观察肝肾功能和不良反应.结果两组均能降低上述指标,但治疗组效果优于对照组,与对照组比较差异有统计学意义(P<0.05).结论罗格列酮对T2DM合并EH的患者有明显的降血糖、降血压、改善胰岛素抵抗和减少尿微量蛋白的作用,而且无明显不良反应.
목적 관찰라격렬동대2형당뇨병(T2DM)합병고혈압(EH)환자적강혈당、강혈압료효이급개선이도소저항화뇨미량백단백적작용.방법 68례T2DM합병EH적환자수궤분위치료조화대조조,치료조35례재복용이갑쌍고화힐사탄적기출상가용라격렬동4 mg/d.대조조불가라격렬동,료정균위16주.비교치료전후량조환자적공복혈당(FBG)、찬후2 h혈당(PBG)、당화혈홍단백(HbA1c)、수축압(SBP)、서장압(DBP)、뇨백단백배설솔(UAE)、공복이도소(FINS)、이도소저항지수(IRI),동시관찰간신공능화불량반응.결과 량조균능강저상술지표,단치료조효과우우대조조,여대조조비교차이유통계학의의(P<0.05).결론 라격렬동대T2DM합병EH적환자유명현적강혈당、강혈압、개선이도소저항화감소뇨미량단백적작용,이차무명현불량반응.
Objective To observe the effect of rosiglitazone on blood glucose, blood pressure, insulin resistance and urine microalbumin in patients with type 2 diabetes mellitus complicated with hypertension. Methods Sixty-eight patients with T2DM complicated with EH were randomly divided into two groups: treatment group and control group. Thirty-five patients in treatment group were treated by metformin hydrochloride, valsartan and rosiglitazone(4 mg/d); 33 patients in control group without rosiglitazone, with a treatment course of 16 weeks for both groups. The fasting blood glucose (FBG), 2 h postprandial blood glucose (PBG),HbA1c, systolic bood pressure (SBP), diastolic blood pressure (DBP),urine albumin excretion (UAE), fasting insulin (FINS), insulin resistance index (IRI) and drug adverse reactions were detected before and after the treatment in both groups. Results The two groups can both lower FBG, PBG, SBP, DBP, UAE, FINS and IRI; but treatment group was superior to control group, there were significant differences (P<0.05). Conclusion Rosiglitazone is effective in treating T2DM complicated with EH, without obvious side effect.