中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2010年
1期
171-174
,共4页
骨髓间充质干细胞%过度训练%心肌细胞%细胞凋亡
骨髓間充質榦細胞%過度訓練%心肌細胞%細胞凋亡
골수간충질간세포%과도훈련%심기세포%세포조망
背景:运动性心肌细胞凋亡及其信号转导和调节机制的研究已成为运动医学领域的重要课题,但其研究成果并未能成功的解释此种现象.从现有的研究成果来看,引入骨髓间充质干细胞对运动性心肌细胞凋亡保护作用的研究还较少.目的:通过骨髓间充质干细胞对心肌细胞凋亡的保护作用以及运动引起心肌细胞凋亡现象的分析,探讨运动引起心肌细胞凋亡的病理病因,及骨髓间充质干细胞对保护机体心肌细胞因运动致使缺氧、缺血、氧化应激等诱导细胞凋亡的作用.方法:应用计算机检索Medline数据库(1994-01/2009-09),以Mesenchymal stem cells,Excessive exercise,Cardiomyocyte,Apoptosis为检索词;应用计算机检索重庆维普数据库(1994-01/2009-09)、清华同方数据库(1994-01/2009-06),以骨髓间充质干细胞、过度训练、心肌细胞、细胞凋亡为检索词.结果与结论:共收集365篇关于干细胞和运动性心肌细胞凋亡的文献,中文120篇,英文245篇.排除发表时间较早、重复及类似研究,纳入68篇符合标准的文献.骨髓间充质干细胞对大强度或超负荷的运动训练所引起的缺氧、缺血、氧化应激等诱导的心肌细胞凋亡有保护作用,从而促进心脏功能的提高和运动性心肌组织疾病的早期康复.
揹景:運動性心肌細胞凋亡及其信號轉導和調節機製的研究已成為運動醫學領域的重要課題,但其研究成果併未能成功的解釋此種現象.從現有的研究成果來看,引入骨髓間充質榦細胞對運動性心肌細胞凋亡保護作用的研究還較少.目的:通過骨髓間充質榦細胞對心肌細胞凋亡的保護作用以及運動引起心肌細胞凋亡現象的分析,探討運動引起心肌細胞凋亡的病理病因,及骨髓間充質榦細胞對保護機體心肌細胞因運動緻使缺氧、缺血、氧化應激等誘導細胞凋亡的作用.方法:應用計算機檢索Medline數據庫(1994-01/2009-09),以Mesenchymal stem cells,Excessive exercise,Cardiomyocyte,Apoptosis為檢索詞;應用計算機檢索重慶維普數據庫(1994-01/2009-09)、清華同方數據庫(1994-01/2009-06),以骨髓間充質榦細胞、過度訓練、心肌細胞、細胞凋亡為檢索詞.結果與結論:共收集365篇關于榦細胞和運動性心肌細胞凋亡的文獻,中文120篇,英文245篇.排除髮錶時間較早、重複及類似研究,納入68篇符閤標準的文獻.骨髓間充質榦細胞對大彊度或超負荷的運動訓練所引起的缺氧、缺血、氧化應激等誘導的心肌細胞凋亡有保護作用,從而促進心髒功能的提高和運動性心肌組織疾病的早期康複.
배경:운동성심기세포조망급기신호전도화조절궤제적연구이성위운동의학영역적중요과제,단기연구성과병미능성공적해석차충현상.종현유적연구성과래간,인입골수간충질간세포대운동성심기세포조망보호작용적연구환교소.목적:통과골수간충질간세포대심기세포조망적보호작용이급운동인기심기세포조망현상적분석,탐토운동인기심기세포조망적병리병인,급골수간충질간세포대보호궤체심기세포인운동치사결양、결혈、양화응격등유도세포조망적작용.방법:응용계산궤검색Medline수거고(1994-01/2009-09),이Mesenchymal stem cells,Excessive exercise,Cardiomyocyte,Apoptosis위검색사;응용계산궤검색중경유보수거고(1994-01/2009-09)、청화동방수거고(1994-01/2009-06),이골수간충질간세포、과도훈련、심기세포、세포조망위검색사.결과여결론:공수집365편관우간세포화운동성심기세포조망적문헌,중문120편,영문245편.배제발표시간교조、중복급유사연구,납입68편부합표준적문헌.골수간충질간세포대대강도혹초부하적운동훈련소인기적결양、결혈、양화응격등유도적심기세포조망유보호작용,종이촉진심장공능적제고화운동성심기조직질병적조기강복.
BACKGROUND: Exercise-induced myocardial cell apoptosis and signal transduction and regulation mechanisms of sports medicine research have become an important issue, but remain poorly understood. Studies concerning the protective effect of bone marrow-derived mesenchymal stem cells (MSCs) to the exercise-induced myocardial cell apoptosis are rarely conducted.OBJECTIVE: To analyze the protective effect of MSCs on myocardial apoptosis and the exercise-induced myocardial cell apoptosis, so as to explore the pathological cause of exercise-induced myocardial apoptosis and the protective effects of MSCs on myocardial cell apoptosis induced by hypoxia, ischemia, and oxidative stress.METHODS: A computer-based online search of articles was performed in Medline database (1994-01/2009-09) with "Mesenchymal stem cells, Excessive exercise, Cardiomyocyte, Apoptosis" as key words and Chongqing PubMed Result NCBI database (1994-01/2009-09), Tsinghua Tong Fang database (1994-01/2009-06), with "bone marrow mesenchymal stem cells, over-training, myocardial cells, apoptosis" as key words. RESULTS AND CONCLUSION: A total of 365 articles on stem cells and exercise-induced myocardial apoptosis were collected, including 120 Chinese and 245 English. Outdate, repetitive and similar studies were excluded, and 68 were included. MSCs display a protection to myocardial cell apoptosis induced by hypoxia, ischemia and oxidative stress caused by high-intensity or overload exercise training, thereby contributing to the improvement of heart function and early rehabilitation of exercise-induced myocardial tissue diseases.
