CAJ | 학술논문

目的探讨合生元治疗烧伤后肠源性感染的机制，为烧伤后肠源性感染的防治探求新途径。方法动态检测大鼠体内的肠道示踪茵JM109易位率和血浆中LPS水平。结果合生元治疗组大鼠体内JM109易位率以及血浆LPS水平明显低于烧伤对照组。结论合生元能够快速补充肠道生理性厌氧菌，坚固肠粘膜外微生物屏障，阻止肠道条件致病茵和LPS经肠壁进入机体组织，对烧伤后肠源性感染有一定的预防和治疗作用。
목적탐토합생원치료소상후장원성감염적궤제，위소상후장원성감염적방치탐구신도경。방법동태검측대서체내적장도시종인JM109역위솔화혈장중LPS수평。결과합생원치료조대서체내JM109역위솔이급혈장LPS수평명현저우소상대조조。결론합생원능구쾌속보충장도생이성염양균，견고장점막외미생물병장，조지장도조건치병인화LPS경장벽진입궤체조직，대소상후장원성감염유일정적예방화치료작용。
Objective To discuss the mechanism of Synbiotics preventing and curing intestinal infection after burned, which might be a new approach to treat intestinal infection after burned. Methods The rats burned experimentally Synbiotics were fed, and then we detected the level of LPS in the rats' plasma and the translocation of rats' intestinal flora at different tims. Results The translocation rate of intestinal flora and level of lipopolysaccharide at different times of the rats which were fed with Synbiotics were significant lower than that of control groups. Conclusion Synbiotics reagent can quickly supplement the deficiency bifidobacteria and lactobacilli caused by burned, stable intestine outpost, and inhibited translocation of the LPS and bacteria.