中华小儿外科杂志
中華小兒外科雜誌
중화소인외과잡지
CHINESE JOURNAL OF PEDIATRIC SURGERY
2011年
1期
6-9
,共4页
王凯%俞松%吕欣%刘远梅%曹江%魏珩%姜富贵%谢祎
王凱%俞鬆%呂訢%劉遠梅%曹江%魏珩%薑富貴%謝祎
왕개%유송%려흔%류원매%조강%위형%강부귀%사의
血管瘤%X连锁凋亡抑制蛋白质%半胱氨酸天冬氨酸蛋白水解酶激活剂
血管瘤%X連鎖凋亡抑製蛋白質%半胱氨痠天鼕氨痠蛋白水解酶激活劑
혈관류%X련쇄조망억제단백질%반광안산천동안산단백수해매격활제
Hemangioma%X-linked inhibitor of apoptosis protein%Second mitochondria- derived activator of caspase
目的 探讨X连锁凋亡抑制蛋白(XIAP)和半胱氨酸天冬氨酸蛋白水解酶激活剂(Smac)在小儿血管瘤消退中的作用.方法 收集未经其他治疗、单纯手术切除并经病理诊断为血管瘤的标本31例,结合Mulliken分类法与增殖细胞核抗原(PCNA)表达对血管瘤进行分类和分期,采用免疫组织化学方法检测XIAP、Smac在血管瘤组织中的表达.结果 18例增殖期血管瘤XIAP、Srnac的积分光密度分别为2421.03±792.91,472.05±182.16;13例退化期血管瘤XIAP、Smac的积分光密度分别为443.24±105.15,2074.10±320.41.血管瘤增殖期Smac的积分光密度明显低于消退期,差异有显著性(P＜0.01);血管瘤增殖期XIAP的积分光密度明显高于消退期,差异有显著性(P＜0.01);XIAP与Smac的表达之间呈负相关关系(r=-0.753,P＜0.01).结论 XIAP、Srmac相互作用可能是导致了血管瘤消退原因之一.
目的 探討X連鎖凋亡抑製蛋白(XIAP)和半胱氨痠天鼕氨痠蛋白水解酶激活劑(Smac)在小兒血管瘤消退中的作用.方法 收集未經其他治療、單純手術切除併經病理診斷為血管瘤的標本31例,結閤Mulliken分類法與增殖細胞覈抗原(PCNA)錶達對血管瘤進行分類和分期,採用免疫組織化學方法檢測XIAP、Smac在血管瘤組織中的錶達.結果 18例增殖期血管瘤XIAP、Srnac的積分光密度分彆為2421.03±792.91,472.05±182.16;13例退化期血管瘤XIAP、Smac的積分光密度分彆為443.24±105.15,2074.10±320.41.血管瘤增殖期Smac的積分光密度明顯低于消退期,差異有顯著性(P＜0.01);血管瘤增殖期XIAP的積分光密度明顯高于消退期,差異有顯著性(P＜0.01);XIAP與Smac的錶達之間呈負相關關繫(r=-0.753,P＜0.01).結論 XIAP、Srmac相互作用可能是導緻瞭血管瘤消退原因之一.
목적 탐토X련쇄조망억제단백(XIAP)화반광안산천동안산단백수해매격활제(Smac)재소인혈관류소퇴중적작용.방법 수집미경기타치료、단순수술절제병경병리진단위혈관류적표본31례,결합Mulliken분류법여증식세포핵항원(PCNA)표체대혈관류진행분류화분기,채용면역조직화학방법검측XIAP、Smac재혈관류조직중적표체.결과 18례증식기혈관류XIAP、Srnac적적분광밀도분별위2421.03±792.91,472.05±182.16;13례퇴화기혈관류XIAP、Smac적적분광밀도분별위443.24±105.15,2074.10±320.41.혈관류증식기Smac적적분광밀도명현저우소퇴기,차이유현저성(P＜0.01);혈관류증식기XIAP적적분광밀도명현고우소퇴기,차이유현저성(P＜0.01);XIAP여Smac적표체지간정부상관관계(r=-0.753,P＜0.01).결론 XIAP、Srmac상호작용가능시도치료혈관류소퇴원인지일.
Objective To investigate the role of X-linked inhibitor of apoptosis protein (XIAP)and second mitochondria- derived activator of caspase (Smac) in hemagioma regression. Methods Thirty-one hemangioma specimens were categorized according to Mulliken's classification and the expression of proliferating cell nuclear antigen (PCNA). The expression of XIAP and Smac were assayed with immunohistochemistry method. Results There were 18 proliferating phase specimens and 13 involuting phase specimens. In the proliferating phase specimens, the IOD(integral optical density) of XIAP and Smac expressions were 2421.03 ± 792.91 and 472.05 ± 182.16 respectively. In the involuting phase specimens,the IOD of XIAP and Smac expressed were 443.24 ± 105.15 and 2074.10 ± 320.41 respectively. In the proliferating phase specimens, the IOD of Smac expression was significantly lower than the IOD in the proliferating phase specimens (P＜0.01 ). In the proliferating phase specimens, the IOD of XIAP expression was significantly higher than the IOD in the involuting phase specimens (P＜0.01). XIAP negatively correlates with Smac (r= -0.753,P＜0.01 ). Conclusions The interaction of XIAP and Smac may resulted in hemangioma regression.
