中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
5期
529-531
,共3页
甘华文%唐其柱%周恒%袁园%纵静
甘華文%唐其柱%週恆%袁園%縱靜
감화문%당기주%주항%원완%종정
心房颤动%尿酸%心肌病,扩张型%氧化性应激
心房顫動%尿痠%心肌病,擴張型%氧化性應激
심방전동%뇨산%심기병,확장형%양화성응격
Atrial fibrillation%Uric acid%Cardiomyopathy,dilated%Stress,oxidative
目的 探讨扩张型心肌病(DCM)患者血尿酸水平与心房颤动(房颤)发生的关系以及临床意义.方法 回顾性分析2010年1月至2011年12月在我院住院治疗的DCM患者的临床资料,比较房颤组(48例)与非房颤组(129例)年龄、心功能分级、血尿酸水平、左心房内径、左心室舒张末内径、左心室射血分数、室间隔厚度、左心室后壁厚度的差异.按尿酸水平分为升高组(88例)与正常组(89例)后比较房颤发生率,并分析尿酸水平对于房颤发生的影响.结果 与非房颤组比较,房颤组患者年龄较大[(64±13)岁比(59±15)岁,P＜0.05],血尿酸水平明显升高[(491±135)μmol/L比(424±121) μmol/L,P＜0.01],左心房内径明显增大[ (48 ±8)mm比(43 ±5)mm,P＜0.01]；血尿酸升高组患者房颤的发生率较正常组高[34.1％ (30/88)比20.2％ (18/89),P＜0.05]；血尿酸水平(OR:1.003,95％ CI:1.000 ～1.006,P＜0.05)和左心房内径(OR:1.147,95％ CI:1.076～1.224,P＜0.01)是DCM患者发生房颤的独立危险因素.结论 血尿酸水平是DCM患者发生房颤的独立危险因素,可以作为DCM患者发生房颤的预测指标.
目的 探討擴張型心肌病(DCM)患者血尿痠水平與心房顫動(房顫)髮生的關繫以及臨床意義.方法 迴顧性分析2010年1月至2011年12月在我院住院治療的DCM患者的臨床資料,比較房顫組(48例)與非房顫組(129例)年齡、心功能分級、血尿痠水平、左心房內徑、左心室舒張末內徑、左心室射血分數、室間隔厚度、左心室後壁厚度的差異.按尿痠水平分為升高組(88例)與正常組(89例)後比較房顫髮生率,併分析尿痠水平對于房顫髮生的影響.結果 與非房顫組比較,房顫組患者年齡較大[(64±13)歲比(59±15)歲,P＜0.05],血尿痠水平明顯升高[(491±135)μmol/L比(424±121) μmol/L,P＜0.01],左心房內徑明顯增大[ (48 ±8)mm比(43 ±5)mm,P＜0.01]；血尿痠升高組患者房顫的髮生率較正常組高[34.1％ (30/88)比20.2％ (18/89),P＜0.05]；血尿痠水平(OR:1.003,95％ CI:1.000 ～1.006,P＜0.05)和左心房內徑(OR:1.147,95％ CI:1.076～1.224,P＜0.01)是DCM患者髮生房顫的獨立危險因素.結論 血尿痠水平是DCM患者髮生房顫的獨立危險因素,可以作為DCM患者髮生房顫的預測指標.
목적 탐토확장형심기병(DCM)환자혈뇨산수평여심방전동(방전)발생적관계이급림상의의.방법 회고성분석2010년1월지2011년12월재아원주원치료적DCM환자적림상자료,비교방전조(48례)여비방전조(129례)년령、심공능분급、혈뇨산수평、좌심방내경、좌심실서장말내경、좌심실사혈분수、실간격후도、좌심실후벽후도적차이.안뇨산수평분위승고조(88례)여정상조(89례)후비교방전발생솔,병분석뇨산수평대우방전발생적영향.결과 여비방전조비교,방전조환자년령교대[(64±13)세비(59±15)세,P＜0.05],혈뇨산수평명현승고[(491±135)μmol/L비(424±121) μmol/L,P＜0.01],좌심방내경명현증대[ (48 ±8)mm비(43 ±5)mm,P＜0.01]；혈뇨산승고조환자방전적발생솔교정상조고[34.1％ (30/88)비20.2％ (18/89),P＜0.05]；혈뇨산수평(OR:1.003,95％ CI:1.000 ～1.006,P＜0.05)화좌심방내경(OR:1.147,95％ CI:1.076～1.224,P＜0.01)시DCM환자발생방전적독립위험인소.결론 혈뇨산수평시DCM환자발생방전적독립위험인소,가이작위DCM환자발생방전적예측지표.
Objective To investigate the association between uric acid and atrial fibrillation in patients with dilated cardiomyopathy.Methods Patients with dilated cardiomyopathy were screened.Age,serum uric acid,NYHA classes,left atrial dimension (LAD),left ventricular end-diastolic dimension (LVEDD),left ventricular ejection fraction (LVEF),interventricular septal thickness (IVST) and left ventricular posterior wall thickness( LVPWT) were compared between the dilated cardiomyopathy patients with atrial fibrillation and those without atrial fibrillation.The incidence of atrial fibrillation was compared between elevated uric acid level patients and normal ones.The effect of serum uric acid on the initiation and perpetuation of atrial fibrillation was also analyzed.Results After univariate analysis,age [ (64 ± 13 )years vs (59 ± 15 )years,P ＜ 0.05 ],uric acid [ (491 ± 135 )μmol/L vs (424 ±121 ) μmol/L,P ＜ 0.01 ],LAD [ (48 ± 8 ) mm vs (43 ± 5 ) mm,P ＜ 0.01 ] were significantly increased in patients with atrial fibrillation compared with non-atrial fibrillation patients.There was a higher incidence of atrial fibrillation in the elevated uric acid group than in the normal uric acid group[ 34.1％ (30/88) vs 20.2％ (18/89),P ＜0.05].After multivariate logistic regression analysis,the independent predictors of atrial fibrillation were uric acid ( OR:1.003,95 ％ CI:1.000-1.006,P ＜ 0.05 ) and LAD ( OR:1.147,95 ％ CI:1.076-1.224,P ＜ 0.01 ).Conclusion There is an independent association between elevated serum uric acid levels and atrial fibrillation in patients with DCM,and the uric acid levels might be a useful predictor of atrial fibrillation.
