中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2012年
7期
499-503
,共5页
万方宁%周家权%朱耀%叶定伟%姚旭东%张世林%戴波%张海梁
萬方寧%週傢權%硃耀%葉定偉%姚旭東%張世林%戴波%張海樑
만방저%주가권%주요%협정위%요욱동%장세림%대파%장해량
前列腺癌根治术%并发症%危险因素%列线图
前列腺癌根治術%併髮癥%危險因素%列線圖
전렬선암근치술%병발증%위험인소%렬선도
Radical prostatectomy%Complication%Risk factors%Nomogram
目的 采用标准化的评分系统分析前列腺癌根治术围手术期并发症的危险因素及构建预测模型. 方法 选取2007年6月至2011年6月行前列腺癌根治术的患者240例,年龄50~82岁,平均70岁.术前均经活检病理诊断为前列腺癌.Gleason评分:<7分95例,≥7分145例.临床分期:T1期1例(0.4%),T2a期5例(2.1%),T2b期7例(2.9%),T2c期162例(67.5%),T3a期26例(10.8%),T3b期39例(16.3%).患者围手术期(术后30 d内)并发症情况依据Clavien-Dindo 标准按严重程度分级,Ⅱ度以上并发症归为有临床意义的并发症,其中直肠损伤4例(1.6%),伤口感染5例(2.0%),深静脉血栓3例(1.2%),尿漏12例(5.0%),淋巴痿11例(4.5%),心肌梗死14例(5.8%),二次手术4例(1.6%).采用倒退法多元Logistic回归筛选危险因素,建立预测围手术期H度及以上并发症的列线图. 结果 围手术期并发症的预测因子中,体质指数(body mass index,BMI)是独立的预后因素(OR值为0.804,P<0.05).通过变量筛选最终的模型包括BMI、N分期、术中出血>200 ml.模型的内部验证显示分辨度C-index为0.633,符合度平均绝对差为0.028.最终根据多因素分析结果绘制了便于临床应用的列线图. 结论 基于标准化的并发症评估数据,我们建立了预测前列腺癌围手术期临床显著并发症的列线图,该列线图在内部验证中显示了良好的效力,有助于前列腺癌个体化的手术治疗.
目的 採用標準化的評分繫統分析前列腺癌根治術圍手術期併髮癥的危險因素及構建預測模型. 方法 選取2007年6月至2011年6月行前列腺癌根治術的患者240例,年齡50~82歲,平均70歲.術前均經活檢病理診斷為前列腺癌.Gleason評分:<7分95例,≥7分145例.臨床分期:T1期1例(0.4%),T2a期5例(2.1%),T2b期7例(2.9%),T2c期162例(67.5%),T3a期26例(10.8%),T3b期39例(16.3%).患者圍手術期(術後30 d內)併髮癥情況依據Clavien-Dindo 標準按嚴重程度分級,Ⅱ度以上併髮癥歸為有臨床意義的併髮癥,其中直腸損傷4例(1.6%),傷口感染5例(2.0%),深靜脈血栓3例(1.2%),尿漏12例(5.0%),淋巴痿11例(4.5%),心肌梗死14例(5.8%),二次手術4例(1.6%).採用倒退法多元Logistic迴歸篩選危險因素,建立預測圍手術期H度及以上併髮癥的列線圖. 結果 圍手術期併髮癥的預測因子中,體質指數(body mass index,BMI)是獨立的預後因素(OR值為0.804,P<0.05).通過變量篩選最終的模型包括BMI、N分期、術中齣血>200 ml.模型的內部驗證顯示分辨度C-index為0.633,符閤度平均絕對差為0.028.最終根據多因素分析結果繪製瞭便于臨床應用的列線圖. 結論 基于標準化的併髮癥評估數據,我們建立瞭預測前列腺癌圍手術期臨床顯著併髮癥的列線圖,該列線圖在內部驗證中顯示瞭良好的效力,有助于前列腺癌箇體化的手術治療.
목적 채용표준화적평분계통분석전렬선암근치술위수술기병발증적위험인소급구건예측모형. 방법 선취2007년6월지2011년6월행전렬선암근치술적환자240례,년령50~82세,평균70세.술전균경활검병리진단위전렬선암.Gleason평분:<7분95례,≥7분145례.림상분기:T1기1례(0.4%),T2a기5례(2.1%),T2b기7례(2.9%),T2c기162례(67.5%),T3a기26례(10.8%),T3b기39례(16.3%).환자위수술기(술후30 d내)병발증정황의거Clavien-Dindo 표준안엄중정도분급,Ⅱ도이상병발증귀위유림상의의적병발증,기중직장손상4례(1.6%),상구감염5례(2.0%),심정맥혈전3례(1.2%),뇨루12례(5.0%),림파위11례(4.5%),심기경사14례(5.8%),이차수술4례(1.6%).채용도퇴법다원Logistic회귀사선위험인소,건립예측위수술기H도급이상병발증적렬선도. 결과 위수술기병발증적예측인자중,체질지수(body mass index,BMI)시독립적예후인소(OR치위0.804,P<0.05).통과변량사선최종적모형포괄BMI、N분기、술중출혈>200 ml.모형적내부험증현시분변도C-index위0.633,부합도평균절대차위0.028.최종근거다인소분석결과회제료편우림상응용적렬선도. 결론 기우표준화적병발증평고수거,아문건립료예측전렬선암위수술기림상현저병발증적렬선도,해렬선도재내부험증중현시료량호적효력,유조우전렬선암개체화적수술치료.
Objective To construct and evaluate a nomogram for predicting the risk of peri-operative complications after radical retro-pubic prostatectomy (RRP) with standard classification criteria.Methods The peri-operative complications and clinicopathological data of 240 patients (50-82 years old) who had undergone RRP for prostate cancer from June 2006 to June 2011 were retrospectively collected.Gleason score:95 cases < 7; 145 patients ≥ 7;Clinical staging:cT1 is 1 case (0.4%),T2a 5 cases (2.1%),T2b 7 cases (2.9%),T2c 162 cases (67.5%),T3a 26 cases (10.8%),T3b 39 cases (16.3%).The peri-operative complications (in 30 days after surgery) were classified by Clavien-Dindo Classification system (the occurrence rates are as follows:rectum injury 1.6%,wound infection 2.0%,deep venous thrombosis 1.2%,urinary leak 5.0%,lymphocele 4.5%,myocardial infarction 5.8%,second look operation 1.6%),and a logistic regression model was used to construct the nomogram.Results BMI,N staging and Blood loss more than 200ml during surgery were independent prognostic factors of RRP morbidity in multivariate logistic regression.The nomogram predicting the risk of peri-operative complications showed relative good concordance index (0.633) and good calibration. Conclusions Based on the clinicopathological factors,a nomogram to predict the probability of peri-operative complications in patients undergone RRP was constructed.This statistical tool may be beneficial in judging operation risk and help consulting with patient before or after surgery.