中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2010年
1期
21-24
,共4页
倪雄%沈志祥%陈芳源%梁辉%汤静燕%陆凤娟%王椿%邵静波%侯健%邹善华%王健民
倪雄%瀋誌祥%陳芳源%樑輝%湯靜燕%陸鳳娟%王椿%邵靜波%侯健%鄒善華%王健民
예웅%침지상%진방원%량휘%탕정연%륙봉연%왕춘%소정파%후건%추선화%왕건민
白血病,淋巴细胞急性%上海%发病率%流行病学%费城染色体
白血病,淋巴細胞急性%上海%髮病率%流行病學%費城染色體
백혈병,림파세포급성%상해%발병솔%류행병학%비성염색체
Leukemia,lymphoblastic,acute%Shanghai%Incidence%Epidenfiology%Philadelphia chromosome
目的 掌握上海市急件淋巴细胞白血病(ALL)的发病率等流行病学资料.方法采用回顾性调查的方式对上海市2002至2006年新诊断的本市户籍的ALL患者进行普查.结果上海市2002至2006年共新诊断ALL患者544例,平均年发病率0.81/10万,较1986至1988年年发病率(0.69/10万)有所上升;其中≤17岁、18～34岁、35～59岁和≥60岁人群的年发病率分别为2.31/10万、0.54/10万、0.46/10万和0.94/10万;按地区分布,崇明县的发病率为0.60/10万,低于其他地区.形态学分型:L_1型占26.2%,L_2型占57.4%,L_3型占16.4%;免疫学分型:B细胞性占80.1%,T细胞性占19.5%,伴髓系抗原表达的ALL患者为20.2%.在成人和儿童患者中,最常见的染色体畸变均为t(9;22).结论上海市ALL的发病率较前有所上升,其中在未成年患者中上升明显,地区分布中崇明县的发病率较低,提示了环境因素在ALL发病中可能的影响.
目的 掌握上海市急件淋巴細胞白血病(ALL)的髮病率等流行病學資料.方法採用迴顧性調查的方式對上海市2002至2006年新診斷的本市戶籍的ALL患者進行普查.結果上海市2002至2006年共新診斷ALL患者544例,平均年髮病率0.81/10萬,較1986至1988年年髮病率(0.69/10萬)有所上升;其中≤17歲、18～34歲、35～59歲和≥60歲人群的年髮病率分彆為2.31/10萬、0.54/10萬、0.46/10萬和0.94/10萬;按地區分佈,崇明縣的髮病率為0.60/10萬,低于其他地區.形態學分型:L_1型佔26.2%,L_2型佔57.4%,L_3型佔16.4%;免疫學分型:B細胞性佔80.1%,T細胞性佔19.5%,伴髓繫抗原錶達的ALL患者為20.2%.在成人和兒童患者中,最常見的染色體畸變均為t(9;22).結論上海市ALL的髮病率較前有所上升,其中在未成年患者中上升明顯,地區分佈中崇明縣的髮病率較低,提示瞭環境因素在ALL髮病中可能的影響.
목적 장악상해시급건림파세포백혈병(ALL)적발병솔등류행병학자료.방법채용회고성조사적방식대상해시2002지2006년신진단적본시호적적ALL환자진행보사.결과상해시2002지2006년공신진단ALL환자544례,평균년발병솔0.81/10만,교1986지1988년년발병솔(0.69/10만)유소상승;기중≤17세、18～34세、35～59세화≥60세인군적년발병솔분별위2.31/10만、0.54/10만、0.46/10만화0.94/10만;안지구분포,숭명현적발병솔위0.60/10만,저우기타지구.형태학분형:L_1형점26.2%,L_2형점57.4%,L_3형점16.4%;면역학분형:B세포성점80.1%,T세포성점19.5%,반수계항원표체적ALL환자위20.2%.재성인화인동환자중,최상견적염색체기변균위t(9;22).결론상해시ALL적발병솔교전유소상승,기중재미성년환자중상승명현,지구분포중숭명현적발병솔교저,제시료배경인소재ALL발병중가능적영향.
Objective To analyse the epidemiological data of acute lymphoblastic leukemia(ALL)in Shanghai.Methods ALL cases in Shanghai from 2002 to 2006 were retrospectively investigated.Results All together there were 544 newly diagnozed All cases.The yearly incidence of All was 0.81/10~5,which was slightly higher in men(0.86/10~5)than in women(0.75/10~5).The age-stratified incidence showed 2.31/10~3 in patients(pts)≤17y,0.54/10~3 in 18-34 y,0.46/10~3 in 35-59 y,and 0.94/10~3 in pts>60y.The incidences in Chongming County was 0.60/10~5,being the lowest in all districts.The morphological types of ALL was L_1(26.2%),L_2(57.4%)and L_3(16.4%);the immunophcnotype was B(80.1%)and T(19.5%).The incidence of ALL with myeloid antigen expression was 20.2%.Genetic examination revealed that chromosome aberration of t(9;22)was the most common one.Conclusions The incidence of ALL in Shanghai is 0.8l/10~5.Compared with the national standard(1986-1998),the incidence in adolescents is obviously increased.Chongming County has the lowest incidence,indicating a role of environment factor in ALL incidence.
