45岁以下行冠状动脉介入治疗女性冠心病患者的临床特点
45세이하행관상동맥개입치료녀성관심병환자적림상특점
Clinical characteristics and outcome comparison between young (≤ 45 years) female and male patients with coronary artery disease undergoing percutaneous coronary intervention
  • 万方数据
    中华心血管病杂志 중화심혈관병잡지
    Chinese Journal of Cardiology
    2010年 3期 248-251 ,共4页

    黄静涵%乔树宾%徐波%李建军%陈珏%刘海波%杨跃进%姚民%吴永建%袁晋青%秦学文%吴元%戴军%尤士杰%胡奉还%马卫华%钱杰%张沛%窦克非%陈纪林%陈在嘉%高润霖

    황정함%교수빈%서파%리건군%진각%류해파%양약진%요민%오영건%원진청%진학문%오원%대군%우사걸%호봉환%마위화%전걸%장패%두극비%진기림%진재가%고윤림

    冠状动脉疾病%血管成形术,经腔,经皮冠状动脉%女(雌)性 冠狀動脈疾病%血管成形術,經腔,經皮冠狀動脈%女(雌)性
    관상동맥질병%혈관성형술,경강,경피관상동맥%녀(자)성
    Coronary disease%Angioplasty,transluminal,percutaneous coronary%Female
    目的 对照评价45岁以下行冠状动脉介入治疗的女性和男性冠心病患者的临床特点及近远期临床疗效.方法 选择2004年4月至2008年2月在阜外心血管病医院择期接受冠状动脉介入治疗的45岁以下所有未绝经的124例女性患者作为女性组,采取整群抽样的方法选择阜外心血管病医院2006至2007年所有择期行冠状动脉介入治疗的45岁以下男性患者430例作为对照(男性组).两组均在术后6个月行临床冠状动脉造影随访,所有患者均临床随访1年.结果 共入选124例女性患者160处病变,430例男性患者665处病变,两组皆完成随访.女性组的血脂异常、陈旧性心肌梗死及吸烟史比例均低于男性组(均P<0.01).左主干病变比例女性组高于男性组(11.2%比2.9%,P<0.01).左前降支比例女性组高于男性组(61.3%比46.9%P=0.016).右冠状动脉病变比例女性组低于男性组(15.6%比30.2%,P<0.01).C型病变比例女性组低于男性组(36.2%比48.9%,P=0.004).分叉病变比例女性组高于男性组(26.9%比11.1%,P<0.01).靶病变长度女性组短于男性组[(20.36±13.37)mm比(23.04±13.86)mm,P=0.027].住院期及1年随访期间,女性组与男性组主要不良心血管事件、血栓发生率及再狭窄率差异无统计学意义.结论 病变位于左主干、前降支和分叉病变的比例45岁以下女性冠心病患者高于45岁以下男性冠心病患者,但是男性患者的冠心病危险因素较多、冠状动脉病变较严重.45岁以下男、女冠心病患者冠状动脉介入治疗的近远期疗效相似.
    목적 대조평개45세이하행관상동맥개입치료적녀성화남성관심병환자적림상특점급근원기림상료효.방법 선택2004년4월지2008년2월재부외심혈관병의원택기접수관상동맥개입치료적45세이하소유미절경적124례녀성환자작위녀성조,채취정군추양적방법선택부외심혈관병의원2006지2007년소유택기행관상동맥개입치료적45세이하남성환자430례작위대조(남성조).량조균재술후6개월행림상관상동맥조영수방,소유환자균림상수방1년.결과 공입선124례녀성환자160처병변,430례남성환자665처병변,량조개완성수방.녀성조적혈지이상、진구성심기경사급흡연사비례균저우남성조(균P<0.01).좌주간병변비례녀성조고우남성조(11.2%비2.9%,P<0.01).좌전강지비례녀성조고우남성조(61.3%비46.9%P=0.016).우관상동맥병변비례녀성조저우남성조(15.6%비30.2%,P<0.01).C형병변비례녀성조저우남성조(36.2%비48.9%,P=0.004).분차병변비례녀성조고우남성조(26.9%비11.1%,P<0.01).파병변장도녀성조단우남성조[(20.36±13.37)mm비(23.04±13.86)mm,P=0.027].주원기급1년수방기간,녀성조여남성조주요불양심혈관사건、혈전발생솔급재협착솔차이무통계학의의.결론 병변위우좌주간、전강지화분차병변적비례45세이하녀성관심병환자고우45세이하남성관심병환자,단시남성환자적관심병위험인소교다、관상동맥병변교엄중.45세이하남、녀관심병환자관상동맥개입치료적근원기료효상사.
    Objective To compare the clinical characteristics and clinical outcomes in young (≤45 years) female and male coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI). Methods Angiographic and clinical data from 124 premenopausal female patients who underwent elective PCI from April 2004 to February 2008 were compared to age-matched 430 male patients who underwent elective PCI between 2006 and 2007 in our department. All patients were treated according to guidelines and coronary angiography was repeated after 6 months. One year clinical follow-up were performed in all patients. Results Incidences of dyslipidemia, the history of myocardial infarction and smoking were significantly lower in female patients than in male patients (all P < 0.01 ). Left main, left anterior descending and bifurcation lesions were more common while type C lesion and right coronary lesion were less common in young female CAD group compared to young male CAD group (P <0. 01 -0. 05). The average lesion length in female patients was significantly longer than that in male patients [ (20. 36±13.37)mm vs.( 23.04±13.86) mm, P < 0. 05 ]. The in-hospital and follow-up incidences of major adverse cardiac events,stent thrombosis and in-stent restenosis were similar between young female and male CAD patients.Conclusions CAD risk factors were less and vessel lesions were more likely to be found at left main, left anterior descending and bifurcation in young female CAD patients compared to young male CAD patients.The clinical outcomes were similar between young female and male CAD patients.
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