中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
3期
18-20
,共3页
儿童%过敏性紫癜%肾炎%组织型纤溶酶原激活物%凝血酶原激活抑制物-1
兒童%過敏性紫癜%腎炎%組織型纖溶酶原激活物%凝血酶原激活抑製物-1
인동%과민성자전%신염%조직형섬용매원격활물%응혈매원격활억제물-1
Child%Henoch-Schonlein purpura%Nephritis%Tissue-type plasminogen activator%Plasminogen activator inhibitor-1
目的 观察过敏性紫癜(HSP)患儿血浆组织型纤溶酶原激活物(t-PA)、凝血酶原激活抑制物-1( PAI-1)水平的变化,探讨其与肾脏损伤的关系.方法 采用双抗体夹心ELISA方法测定血浆t-PA、PAI-1并加以分析.结果 合并肾脏损害(A)组t-PA、PAI-1急性期和恢复期均高于对照组,t-PA/PAI-1均低于对照组,差异有统计学意义(P均＜ 0.01)；无肾脏损害(B)组t-PA、PAI-1急性期升高,与正常对照组比较差异有统计学意义(P均＜0.01),恢复期降至正常,t-PA/PAI-1急性期和恢复期与正常对照组比较差异无统计学意义；A组t-PA急性期低于B组,恢复期高于B组,PAI-1急性期和恢复期均高于B组,t-PA/PAI-1均低于B组,差异有统计学意义(P均＜0.01).结论 纤溶系统功能的削弱可能与过敏性紫癜肾脏损伤的发生有关.
目的 觀察過敏性紫癜(HSP)患兒血漿組織型纖溶酶原激活物(t-PA)、凝血酶原激活抑製物-1( PAI-1)水平的變化,探討其與腎髒損傷的關繫.方法 採用雙抗體夾心ELISA方法測定血漿t-PA、PAI-1併加以分析.結果 閤併腎髒損害(A)組t-PA、PAI-1急性期和恢複期均高于對照組,t-PA/PAI-1均低于對照組,差異有統計學意義(P均＜ 0.01)；無腎髒損害(B)組t-PA、PAI-1急性期升高,與正常對照組比較差異有統計學意義(P均＜0.01),恢複期降至正常,t-PA/PAI-1急性期和恢複期與正常對照組比較差異無統計學意義；A組t-PA急性期低于B組,恢複期高于B組,PAI-1急性期和恢複期均高于B組,t-PA/PAI-1均低于B組,差異有統計學意義(P均＜0.01).結論 纖溶繫統功能的削弱可能與過敏性紫癜腎髒損傷的髮生有關.
목적 관찰과민성자전(HSP)환인혈장조직형섬용매원격활물(t-PA)、응혈매원격활억제물-1( PAI-1)수평적변화,탐토기여신장손상적관계.방법 채용쌍항체협심ELISA방법측정혈장t-PA、PAI-1병가이분석.결과 합병신장손해(A)조t-PA、PAI-1급성기화회복기균고우대조조,t-PA/PAI-1균저우대조조,차이유통계학의의(P균＜ 0.01)；무신장손해(B)조t-PA、PAI-1급성기승고,여정상대조조비교차이유통계학의의(P균＜0.01),회복기강지정상,t-PA/PAI-1급성기화회복기여정상대조조비교차이무통계학의의；A조t-PA급성기저우B조,회복기고우B조,PAI-1급성기화회복기균고우B조,t-PA/PAI-1균저우B조,차이유통계학의의(P균＜0.01).결론 섬용계통공능적삭약가능여과민성자전신장손상적발생유관.
Objective To observe the changes of plasma levels of tissue-type plasminogen activator and inhibitor-1,and its relationship with kidney damage in children with Henoch-Schonlein Purpura.Methods Plasma levels of tissue-type plasminogen activator ( t-PA) and plasminogen activator inhibitor-l( PAI-1) were measured by enzyme-linked immunosorhent assay.Results Plasma levels of t-PA and PAI-1 in children with Henoch-Schonlein Purpura with kidney damage( group A) were significantly higher than those of the controls in acute phase and recovery phase (P ＜ 0.01).The levels of t-PA/PAI-I in group A were significantly lower than those of the controls in acute phase and recovery phase (P ＜ 0.01) ; Plasma levels of t-PA and PAI-1 in children with Henoch-Schonlein Purpura without kidney damage( group B) were significantly higher than those of the controls in acute phase ( P ＜ 0.01) and reduced to normal in recovery phase.The levels of t-PA/PAI-1 in group B were normal in acute phase and recovery phase; The levels of t-PA in group A were significantly lower in acute phase and significantly higher in recovery phase than those in group B ( P ＜ 0.01).The levels of PAI-I in group A were significantly higher than those in group B in acute phase and recovery phase (P ＜ 0.01).The levels of t-PA/PAI-1 in group A were significantly lower than those in group B in acute phase and recovery phase (P ＜ 0.001).Conclusions Impairment of the fibrinolytic system maybe related to the kidney damage in children with Henoch-Schonlein Purpura.
