CAJ | 학술논문

目的探讨阿托伐他汀的降脂疗效及对老年脑梗死伴高血脂患者颈动脉粥样硬化斑块的影响.方法采取治疗前后自身对照比较的方法,选择50例脑梗死合并颈动脉粥样硬化斑块患者,给予阿托伐他汀10 mg,qn总疗程1年,分别测定治疗前及治疗后6～12个月的血脂、颈动脉内膜-中层厚度、颈动脉斑块面积的变化.结果阿托伐他汀治疗6～12个月后,TC、LDL-C、TG降低(P<0.05),HDL-C升高(P<0.01);颈动脉的内径有所扩大,颈动脉斑块缩小,尤以12个月后改变显著(P<0.01).结论阿托伐他汀降脂疗效确切,减少并稳定斑块的作用.
목적 탐토아탁벌타정적강지료효급대노년뇌경사반고혈지환자경동맥죽양경화반괴적영향.방법 채취치료전후자신대조비교적방법,선택50례뇌경사합병경동맥죽양경화반괴환자,급여아탁벌타정10 mg,qn총료정1년,분별측정치료전급치료후6～12개월적혈지、경동맥내막-중층후도、경동맥반괴면적적변화.결과 아탁벌타정치료6～12개월후,TC、LDL-C、TG강저(P<0.05),HDL-C승고(P<0.01);경동맥적내경유소확대,경동맥반괴축소,우이12개월후개변현저(P<0.01).결론 아탁벌타정강지료효학절,감소병은정반괴적작용.
Objective To investigate the effect of atorvastatin on arteriosclerosis plaque of carotid artery in elder patients with cerebral infarction and hypercholesterolemia. Methods With self-comparsion of before and after treatment,50 subjects with arteriosclerosis plaque of carotid artery were given atorvastatin 10 mg,qn for 12 months. After treatment 6 and 12 months, arteriosclerosis plaque of carotid artery、 intima-media thickness and peak index were measured in all patients. Results After 6 and 12 months adminstration of atorvastatin, TC、TG、LDL-C were all reduced (P<0.05), and HDL-C was elevated (P<0.01) in all patients.The initial diameter of carotid was significantly enlarged in 12 months (P<0.01). The size of plaque decreased (P<0.01) in 12 months after atorvastatin therapy than before(P<0.01). Conclusion The effect of atorvastatin is certain and it can stabilize the plaque of carotid artery.