CAJ | 학술논문

目的探讨高强度聚焦超声(HIFU)治疗结直肠癌术后肝转移的临床疗效及其安全性.方法 16例大肠癌术后肝转移患者28个病灶行HIFU治疗,观察患者生命体征、主要脏器功能、影像学检查(CT或MRI等)、并发症和肿瘤转归的情况.结果所有患者治疗后生命体征平稳,肝、肾功能正常,6个月随访发现6个病灶体积缩小超过80%、18个病灶体积缩小30%～50%,4个病灶体积变化不明显;16例患者中1例失访.15例随访6～24个月,其中5例患者因病灶转移播散于术后6月内死亡,中位生存时间为13个月;1例患者皮肤出现条索状灼痕,经治疗1周后愈合.1例患者治疗区的胸腹部皮肤、皮下出现轻度水肿.结论 HIFU治疗结肠癌术后肝转移病灶是一种非侵入性、安全、有效的治疗手段.
목적 탐토고강도취초초성(HIFU)치료결직장암술후간전이적림상료효급기안전성.방법 16례대장암술후간전이환자28개병조행HIFU치료,관찰환자생명체정、주요장기공능、영상학검사(CT혹MRI등)、병발증화종류전귀적정황.결과 소유환자치료후생명체정평은,간、신공능정상,6개월수방발현6개병조체적축소초과80%、18개병조체적축소30%～50%,4개병조체적변화불명현;16례환자중1례실방.15례수방6～24개월,기중5례환자인병조전이파산우술후6월내사망,중위생존시간위13개월;1례환자피부출현조색상작흔,경치료1주후유합.1례환자치료구적흉복부피부、피하출현경도수종.결론 HIFU치료결장암술후간전이병조시일충비침입성、안전、유효적치료수단.
Objective To investigate the clinical efficacy and safety of the high-intensity focused ultrasound therapy in patients with colorectal liver metastases. Methods 28colorectal lesions in 16 patients with liver metastases after HIFU treatment lines observed patient vital signs,the main organ,imaging studies (CT or MRI,etc. ) ,complications and prognosis of cancer cases. Results All patients with stable vital signs after treatment, liver, kidney function was normal,6-month follow up, six more than 80% reduced lesion size,lesion size decreased in 18 of 30% to 50% ,4tumor volume did not change significantly; 16 patients, 1 patient was lost. 15 cases were followed uPfor 6 to 24 months,5 patients were transferred because of lesions disseminated in death within 6 months after surgery, calculated with the Kaplan-Meier median survival time was 13 months; 1 patient skin burning streak marks, healed after 1 week after treatment. 1 patient treatment areas of the chest skin, mild subcutaneous edema. Conclusion The treatment of patients with liver metastasis of colon cancer lesions was a non-invasive, safe and effective treatment.