CAJ | 학술논문

目的探讨血浆B型钠尿肽水平与血液透析患者干体重的关系及其评估干体重的临床意义.方法选取血液透析患者中实际体重超出干体重的25例患者,所有研究对象经过2周逐渐透析脱水下调体重达到临床干体重；并测定患者下调体重前、后的血浆B型钠尿肽、心胸比值及体重,并观察临床表现.结果 (1)患者下调体重后血浆B型钠尿肽、心胸比值与下调体重前比较差异有统计学意义(P＜0.01)；(2)患者体重下调前、后B型钠尿肽之差与体重下调前、后心胸比值之差呈显著相关(r=0.67,P＜0.01)；体重下调前、后B型钠尿肽之差与体重下调前、后体重之差呈显著相关(r=0.73,P＜O.01).结论血浆B型钠尿肽水平能反映血液透析患者体内的容量负荷状态,测定B型钠尿肽可以应用于评估血液透析患者的干体重.
목적 탐토혈장B형납뇨태수평여혈액투석환자간체중적관계급기평고간체중적림상의의.방법 선취혈액투석환자중실제체중초출간체중적25례환자,소유연구대상경과2주축점투석탈수하조체중체도림상간체중；병측정환자하조체중전、후적혈장B형납뇨태、심흉비치급체중,병관찰림상표현.결과 (1)환자하조체중후혈장B형납뇨태、심흉비치여하조체중전비교차이유통계학의의(P＜0.01)；(2)환자체중하조전、후B형납뇨태지차여체중하조전、후심흉비치지차정현저상관(r=0.67,P＜0.01)；체중하조전、후B형납뇨태지차여체중하조전、후체중지차정현저상관(r=0.73,P＜O.01).결론 혈장B형납뇨태수평능반영혈액투석환자체내적용량부하상태,측정B형납뇨태가이응용우평고혈액투석환자적간체중.
Objective To investigate the relation between B-type natriuretic peptide (BNP) level and the dry weight of maintenance hemodialysis patients and the clinical significance of B-type natriuretic peptide (BNP) level to estimate the dry weight.Methods Select 25 hemodialysis patients whose actual weight beyond dry weight,All patients are regulated down to clinical dry weight by dialyzing water in two weeks.Detect blood plasma B-type natriure-tic peptidecardiac thoracic rate and weight before and after regulate down weight.Results (1) Blood plasma B-type natriure-tic peptide and cardiac thoracic rate descend notable from before to after regulate down weight ( P ＜ 0.01 ) ; (2) Variation of blood plasma B-type natriuretic peptide notable corelated with variation of cardiac thoracic rate before and after regulate down weight ( r =0.67,P ＜ 0.01),variation of weight notable corelated with variation of blood plasma B-type natriurefic pe-ptide( r =0.73,P ＜ 0.01 ).Conclusion Blood plasma B-type natriuretic peptide can reflex volume load state of maintenance hemodialysis patients,B-type natriuretic peptide determination can estimate the dry weight of hemodialysis patient.