国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
2期
94-96
,共3页
SPARC%胰岛素抵抗%2型糖尿病%肥胖
SPARC%胰島素牴抗%2型糖尿病%肥胖
SPARC%이도소저항%2형당뇨병%비반
SPARC%Insulin resistance%Type 2 diabetes mellitus%Obesity
富含半胱氨酸的酸性分泌蛋白(SPARC)主要来源于脂肪组织.血循环中SPARC水平与胰岛素抵抗、肥胖及2型糖尿病( T2DM)有关.胰岛素和瘦素能促进脂肪组织SPARC的分泌.SPARC可能参与了肥胖、T2DM及其并发症的发生、发展,有望成为治疗T2DM及代谢综合征的新靶点.
富含半胱氨痠的痠性分泌蛋白(SPARC)主要來源于脂肪組織.血循環中SPARC水平與胰島素牴抗、肥胖及2型糖尿病( T2DM)有關.胰島素和瘦素能促進脂肪組織SPARC的分泌.SPARC可能參與瞭肥胖、T2DM及其併髮癥的髮生、髮展,有望成為治療T2DM及代謝綜閤徵的新靶點.
부함반광안산적산성분비단백(SPARC)주요래원우지방조직.혈순배중SPARC수평여이도소저항、비반급2형당뇨병( T2DM)유관.이도소화수소능촉진지방조직SPARC적분비.SPARC가능삼여료비반、T2DM급기병발증적발생、발전,유망성위치료T2DM급대사종합정적신파점.
Secreted protein acidic and rich in cysteine (SPARC) was mainly secreted by adipose tissues.Circulating SPARC levels were related with insulin resistance,obesity and type 2 diabetes mellitus (T2DM).Insulin and leptin can promote the secretion of SPARC in adipose tissues.SPARC may participate in the occurance and development of obesity,T2DM and its complications.It may become a new target for the therapy of T2DM and metabolic syndrome.
