CAJ | 학술논문

糖皮质激素作为一种抗炎介质在慢性肾脏病的治疗中有重要地位,而糖皮质激素的使用可使患者发生胰岛素抵抗或使原有胰岛素抵抗加重.胰岛素抵抗与肾脏病变关系密切,可作为慢性肾脏病发生发展的独立危险因素,并加重肾脏病变.慢性肾脏病患者亦可有胰岛素抵抗表现,这给慢性肾脏病患者的糖皮质激素治疗造成了困难,本文就这一问题进行综述.
당피질격소작위일충항염개질재만성신장병적치료중유중요지위,이당피질격소적사용가사환자발생이도소저항혹사원유이도소저항가중.이도소저항여신장병변관계밀절,가작위만성신장병발생발전적독립위험인소,병가중신장병변.만성신장병환자역가유이도소저항표현,저급만성신장병환자적당피질격소치료조성료곤난,본문취저일문제진행종술.
Glucocorticoids have remained important anti-inflammatory agents in the treatment of chronic kidney disease (CKD).However,the use of glucocorticoids can invoke or enhance insulin resistance,which is closely associated with renal injury and serves as an independent risk of the occurrence and progression of CKD.On the other hand,CKD patients may have insulin resistance,which hampers the use of glucocorticoids in these patients.