CAJ | 학술논문

以羟丙甲基纤维素(HPMC)为主要载体制备了丹皮酚(PN)的缓释骨架片.在载体中添加不同的释放调节剂,比较了对药物释放的影响;考察了不同黏度的HPMC及其用量对释放的影响;通过对体外释放数据进行零级方程、Higuchi和Peppas方程拟合,探讨了药物的释放机制.结果表明,以微晶纤维素为释放调节剂所制备的骨架片呈现良好的缓释特征,2h释放31%,6h释放66%,12h释放99%.药物释放数据可以用Peppas方程(Q=Ktn)进行很好拟合,并且有0.45<n<0.89(n=0.6685),提示药物的释放机制为非Fichian扩散,即药物是通过凝胶层扩散和骨架溶蚀控制的释放.
이간병갑기섬유소(HPMC)위주요재체제비료단피분(PN)적완석골가편.재재체중첨가불동적석방조절제,비교료대약물석방적영향;고찰료불동점도적HPMC급기용량대석방적영향;통과대체외석방수거진행령급방정、Higuchi화Peppas방정의합,탐토료약물적석방궤제.결과표명,이미정섬유소위석방조절제소제비적골가편정현량호적완석특정,2h석방31%,6h석방66%,12h석방99%.약물석방수거가이용Peppas방정(Q=Ktn)진행흔호의합,병차유0.45<n<0.89(n=0.6685),제시약물적석방궤제위비Fichian확산,즉약물시통과응효층확산화골가용식공제적석방.
Paeonol hydrogel matrix tablets have been prepared using hydroxypropyl methylcellulose(HPMC)as the main carrier.Several hydrophilic excipients were used to modify the release of paeonol.The effects of viscosity and amount of HPMC on the release properties were investigated.The release mechanism was also analyzed by fitting the release data to a zero-order equation and the Higuchi and Peppas equations.The results showed that tablets based on an HPMC matrix with microcrystalline cellulose(MCC) as the modulator had good sustained-release characteristics.The amounts of drug released in 2h,6h,and 12h were 31%,66% and 99%,respectively.The release data were fitted to a Peppas equation(Q=Ktn),with 0.45<n<0.89(n=0.6685),indicating that mechanism of drug release involves a combination of diffusion and erosion effects.