中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2009年
17期
6-7
,共2页
母婴血型不合%ABO血型抗体%抗体效价%新生儿溶血病
母嬰血型不閤%ABO血型抗體%抗體效價%新生兒溶血病
모영혈형불합%ABO혈형항체%항체효개%신생인용혈병
Maternal and infant blood group incompatibility%ABO blood group antibodies%antibody titer%HDN
目的 检测孕妇产前IgG抗A/B 抗体效价,探讨孕妇产前不规则抗体筛查在新生儿溶血病预防中的意义.方法 对317例夫妻血型不合的孕妇进行产前抗A/B IgG抗体效价测定,并对IgG类抗A/B效价≥1:64的孕妇给予临床干预,观察产后婴儿是否发生溶血,溶血出现的时间及程度;同时随机选择317例夫妻血型不合,产前未做不规则抗体筛查的产妇,调查其婴儿是否发生溶血,溶血出现的时间及程度.结果 ①试验组,新生儿溶血发生13例(4.10%),其中24 h内发生者1例,48 h发生者3例,72 h发生者3例,>72 h发生者6例;对照组,新生儿溶血发生49例(15.46%),其中24 h内发生者14例,48 h发生者17例,72 h发生者15例,>72 h发生者3例;两组比较有统计学意义(P<0.05);②对照组新生儿黄疸平均出现时间(53.39±26.95)h;试验组(77.54±29.64)h,试验组新生儿黄疸出现时间较对照组晚;③对照组黄疸程度较试验组严重的,两组比较差异有统计学意义(P<0.05).结论 孕妇产前ABO血清IgG抗A/B 抗体效价测定可作为判断胎儿出生后是否发生新生儿溶血病的筛查指标.对降低新生儿母婴血型不合引起的新生儿溶血病具有积极作用.
目的 檢測孕婦產前IgG抗A/B 抗體效價,探討孕婦產前不規則抗體篩查在新生兒溶血病預防中的意義.方法 對317例伕妻血型不閤的孕婦進行產前抗A/B IgG抗體效價測定,併對IgG類抗A/B效價≥1:64的孕婦給予臨床榦預,觀察產後嬰兒是否髮生溶血,溶血齣現的時間及程度;同時隨機選擇317例伕妻血型不閤,產前未做不規則抗體篩查的產婦,調查其嬰兒是否髮生溶血,溶血齣現的時間及程度.結果 ①試驗組,新生兒溶血髮生13例(4.10%),其中24 h內髮生者1例,48 h髮生者3例,72 h髮生者3例,>72 h髮生者6例;對照組,新生兒溶血髮生49例(15.46%),其中24 h內髮生者14例,48 h髮生者17例,72 h髮生者15例,>72 h髮生者3例;兩組比較有統計學意義(P<0.05);②對照組新生兒黃疸平均齣現時間(53.39±26.95)h;試驗組(77.54±29.64)h,試驗組新生兒黃疸齣現時間較對照組晚;③對照組黃疸程度較試驗組嚴重的,兩組比較差異有統計學意義(P<0.05).結論 孕婦產前ABO血清IgG抗A/B 抗體效價測定可作為判斷胎兒齣生後是否髮生新生兒溶血病的篩查指標.對降低新生兒母嬰血型不閤引起的新生兒溶血病具有積極作用.
목적 검측잉부산전IgG항A/B 항체효개,탐토잉부산전불규칙항체사사재신생인용혈병예방중적의의.방법 대317례부처혈형불합적잉부진행산전항A/B IgG항체효개측정,병대IgG류항A/B효개≥1:64적잉부급여림상간예,관찰산후영인시부발생용혈,용혈출현적시간급정도;동시수궤선택317례부처혈형불합,산전미주불규칙항체사사적산부,조사기영인시부발생용혈,용혈출현적시간급정도.결과 ①시험조,신생인용혈발생13례(4.10%),기중24 h내발생자1례,48 h발생자3례,72 h발생자3례,>72 h발생자6례;대조조,신생인용혈발생49례(15.46%),기중24 h내발생자14례,48 h발생자17례,72 h발생자15례,>72 h발생자3례;량조비교유통계학의의(P<0.05);②대조조신생인황달평균출현시간(53.39±26.95)h;시험조(77.54±29.64)h,시험조신생인황달출현시간교대조조만;③대조조황달정도교시험조엄중적,량조비교차이유통계학의의(P<0.05).결론 잉부산전ABO혈청IgG항A/B 항체효개측정가작위판단태인출생후시부발생신생인용혈병적사사지표.대강저신생인모영혈형불합인기적신생인용혈병구유적겁작용.
Objective The purpose of prenatal detection of IgG anti-A/B antibody titers to explore prenatal screening for irregular antibodies in the prevention of hemolytic disease of newborn significance.Methods 317 cases of pregnant women detected for prenatal anti-A/B IgG antibody titer of couple's blood type incompatibility,and IgG anti-A/B titer ≥ 1:64 to administrate clinical interventions for pregnant women to observe the occurrence of post-natal baby hemolysis,hemolysin appears time and level; at the same time 317 cases of randomly selected couples blood group incompatibility,prenatal screening not done irregular maternal antibodies to investigate whether their infants hemolysis,hemolytic emerging time and extent.Results ①In the experimental group,13 cases of neonatal hemolytic occurred(4.10% ),which occurred within 24 h was one case,48 h occurred in 3 cases,72 h occurs 3 cases,>72 h were 6 cases occurred; control group,49 occurred in neonatal hemolytic cases(15.46% ),which occurs within 24 h of 14 cases,48 h occurs 17 cases,72 h occurred in 15 cases,>72 h were 3 cases occurred; two groups was statistically significance(P<0.05).②In the experimental group,average time appearing of jaundice was(77.54±29.64)h; control group,(53.39±26.95)h,the experimental group is later than control group;③The degree of jaundice in the control group was severer than experimental group,two groups was statistically significance(P<0.05).Conclusion ABO prenatal serum IgG anti-A/B antibody titer determination as to determine whether the fetus after birth occurred in hemolytic disease of newborn screening indicators.To reduce maternal and child neonatal ABO hemolytic disease of newborns caused by having a positive effect.
