CAJ | 학술논문

合成了两种新型钌多吡啶配合物:[Ru(bpy)2(PyIP)]2+(1)和[Ru(dmb)2(PyIP)]2+ (2),采用元素分析、电喷雾质谱和1H NMR对其进行了表征.用紫外滴定、荧光滴定以及粘度的方法研究了两配合物与DNA的相互作用.实验结果表明,两种配合物均以插入方式与DNA结合,然而配合物1与DNA的结合比配合物2的要大.这种现象是由于辅助配体的不同而引起的.
합성료량충신형조다필정배합물:[Ru(bpy)2(PyIP)]2+(1)화[Ru(dmb)2(PyIP)]2+ (2),채용원소분석、전분무질보화1H NMR대기진행료표정.용자외적정、형광적정이급점도적방법연구료량배합물여DNA적상호작용.실험결과표명,량충배합물균이삽입방식여DNA결합,연이배합물1여DNA적결합비배합물2적요대.저충현상시유우보조배체적불동이인기적.
Two novel polypyridyl {PyIP = 2-(pyren-1-yl)-1H-imidazo[4,5-f][1,10] phenanthroline, bpy = 2,2′-bipyridine, dmb = 4,4′-dimethyl-2,2′-bipyridine} ruthenium(II) complexes [Ru(bpy)2(PyIP)]2+ (1) and [Ru(dmb)2(PyIP)]2+ (2) have been synthesized and characterized by elemental analysis, ES-MS and 1H NMR spectroscopy. The DNA-binding of these complexes were investigated by spectroscopic methods and viscosity measurements. The experimental results indicate that both complexes 1 and 2 bind to calf thymus DNA in classical intercalation mode, and however, complex 1 intercalated more strongly than complex 2, due to the different ancillary ligands.