CAJ | 학술논문

本综述分析了中药现代研究与发展的挑战.中药是国际上医学、生物医学和制药机构作为一个有价值药用制剂的潜在来源.研究和发展中药,第一个挑战是评估疗效、药理特性、作用机理和有效成分;第二是要及时总结,并发展可靠的方法学,以提升中药研究的质量并通过提供适宜的评估方法,利于管理部门的法规制定及中药产品的注册;第三是研究药物代谢和药代动力学;第四是采用新的"组学"技术和工具应用于中药的研究开发及中药现代化过程.因此,需要运用现代方法去研究、开发和探索充满潜力的中草药资源,特别是药用植物.
본종술분석료중약현대연구여발전적도전.중약시국제상의학、생물의학화제약궤구작위일개유개치약용제제적잠재래원.연구화발전중약,제일개도전시평고료효、약리특성、작용궤리화유효성분;제이시요급시총결,병발전가고적방법학,이제승중약연구적질량병통과제공괄의적평고방법,리우관리부문적법규제정급중약산품적주책;제삼시연구약물대사화약대동역학;제사시채용신적"조학"기술화공구응용우중약적연구개발급중약현대화과정.인차,수요운용현대방법거연구、개발화탐색충만잠력적중초약자원,특별시약용식물.
In this review, the author analyzed the challenges in modern research and development of Traditional Chinese Medicine (TCM) products. Chinese traditional and herb drugs have gained interest from the international medical, biomedical and pharmaceutical institutions as potential source of valuable medicinal agents. For the researches and development of TCMs, the first challenge is to evaluate the efficacy, pharmacological properties, action mechanism and active chemical constituents. The second one is to summarize the issues for developing safety research methodologies, to improve the quality and enhance the value of research in TCM and to provide appropriate evaluation methods to facilitate the regulation and registration of TCM products, and the third is to study drug metabolism and pharmacokinetics, and the fourth is to apply new "-omics" techniques and tools in new revolution in drug discovery-development and to impact on modern research of TCM products. This interest is needed to apply modern research on the development and exploration of the promising medical potential resources of Chinese traditional and herbal drugs, especially from medicinal plants.