CAJ | 학술논문

目的：了解可溶性Fas(sFas)在肝癌细胞及慢性肝炎中的作用。方法：采用双抗体夹心ELISA法对18例慢性乙型肝炎(CH)患者、12例肝癌患者(HCC)和6例正常对照者(NC)血清sFas进行检测，并对CH患者血清sFas水平与肝细胞损害程度进行相关性分析。结果：HCC患者血清sFas水平比CH患者及NC组明显升高(均P<0.01)；CH患者血清sFas水平与NC组比较差异有显著性(P<0.01)。CH患者血清sFas水平与血清ALT/AST，ALB，PTA呈负相关(P<0.01)，与血清总胆红素呈正相关(P<0.01)。结论：sFas可阻止肝癌细胞凋亡的发生，而慢性乙型肝炎患者sFas与肝脏重症程度具有相关性。
목적：료해가용성Fas(sFas)재간암세포급만성간염중적작용。방법：채용쌍항체협심ELISA법대18례만성을형간염(CH)환자、12례간암환자(HCC)화6례정상대조자(NC)혈청sFas진행검측，병대CH환자혈청sFas수평여간세포손해정도진행상관성분석。결과：HCC환자혈청sFas수평비CH환자급NC조명현승고(균P<0.01)；CH환자혈청sFas수평여NC조비교차이유현저성(P<0.01)。CH환자혈청sFas수평여혈청ALT/AST，ALB，PTA정부상관(P<0.01)，여혈청총담홍소정정상관(P<0.01)。결론：sFas가조지간암세포조망적발생，이만성을형간염환자sFas여간장중증정도구유상관성。
Objective　To study the effects of sFas in hepatocellular cancer (HCC) and chronic hepatitis (CH). Methods　The serum sFas was detected in 18 patients with HCC, 12 patients with CH and 6 cases of normal control by ELISA. Results　The serum sFas in HCC was obviously increased and had significant difference with the patients of CH and normal control (P<0.01). The serum sFas had positive correlation with the serum TBIL(P<0.01), but negative correlation with the ALB, PTA and the ratio of ALT/AST(P<0.01).Conclusions　sFas may resist the occurrence of HCC apoptosis. In CH, sFas has correlation with the severity of CH. The role of sFas in viral hepatitis is uncertain.