CAJ | 학술논문

目的分析出生前后血铅负荷对要幼儿智商发育的影响。方法本文采用前瞻性流行病学的方法，对妊娠3个月左右的孕妇进行追踪观察，直至分娩，继之观察其子女至2岁。期间分别采集孕妇妊娠3、6月静脉血，婴儿出生后6、12、18、24月的指血做血铅分析。同时对幼儿智商发育水平及可能影响幼儿智商发育的因素如孕妇情况，分娩情况和幼儿喂养情况进行调查。结果孕妇血铅水平比较低，要幼儿出生后血铅逐渐增加，但其平均血铅水平均低于100μg/L。98.76％的婴幼儿智商水平在正常范围之内。单因素分析表明，妊娠6月血铅与婴儿18月智商呈负相关。多元回归分析发现妊娠6月和3月血铅分别与婴幼儿18月和24月智商呈负相关。而出生后血铅与幼儿智商关系不明显。结论提示胎儿期铅暴露对婴幼儿智商发育有一定的负影响。
목적분석출생전후혈연부하대요유인지상발육적영향。방법본문채용전첨성류행병학적방법，대임신3개월좌우적잉부진행추종관찰，직지분면，계지관찰기자녀지2세。기간분별채집잉부임신3、6월정맥혈，영인출생후6、12、18、24월적지혈주혈연분석。동시대유인지상발육수평급가능영향유인지상발육적인소여잉부정황，분면정황화유인위양정황진행조사。결과잉부혈연수평비교저，요유인출생후혈연축점증가，단기평균혈연수평균저우100μg/L。98.76％적영유인지상수평재정상범위지내。단인소분석표명，임신6월혈연여영인18월지상정부상관。다원회귀분석발현임신6월화3월혈연분별여영유인18월화24월지상정부상관。이출생후혈연여유인지상관계불명현。결론제시태인기연폭로대영유인지상발육유일정적부영향。
Objective To explore the effects of prenatal and postnatal exposure to lead on intelligence quotient of infants. Methods A prospective epidemiological study was carried out among the pregnant women during the period from 3-month gestation to delivery,and their infants during the period from birth to 2 years old. The levels of blood lead of the venous blood samples of pregnant women at the 3th and 6th month of gestation,and of fingers blood samples of infants at the age of 6,12,18 and 24 months were determined. The levels of intelligence quotient(IQ) of the infants and their related affecting factors, such as individual and family status of the pregnant women, delivery, and infant feeding were analyzed. Results The lower blood lead levels were observed among pregnant women. The blood lead levels increased gradually among infants after birth,but their average levels were below 100 μg/L. In 98. 76％ of the observed infants normal IQ levels were found. Single factor analysis showed a negative correlation between the blood lead levels of pregnant women at 6th month gestation and the IQ levels of infants aged 18 month. Multiple regression analysis showed a negative correlations between the blood lead levels of pregnant women at 6th month gestation and IQ levels of infants aged 18 months ,and between the blood lead levels of pregnant women at 3th month gestation and IQ levels of infants aged 24 months. No significant correlation was observed between the blood lead levels and IQ levels of infants after birth. Conclusion The fetal lead exposure presented a certain negative effects on IQ levels of infants.