CAJ | 학술논문

目的：探索提高恶性脑胶质瘤治疗效果的新途径。方法：用人参皂甙(ginsenoside，GS)与白细胞介素2(IL-2)协同诱导人外周血单个核细胞(PBMC)制成GS-LAK细胞，用MTT法测定其对恶性脑胶质瘤细胞(BT325)的杀伤活性，并与LAK细胞相比较。结果：效应细胞GS-LAK在增殖数量和杀伤恶性脑胶质瘤细胞活性等方面均优于LAK细胞，且IL-2用量减少。结论：采用GS-LAK细胞，可提高效应细胞的数量和活性，为恶性脑胶质瘤的免疫治疗打下了理论基础。
목적：탐색제고악성뇌효질류치료효과적신도경。방법：용인삼조대(ginsenoside，GS)여백세포개소2(IL-2)협동유도인외주혈단개핵세포(PBMC)제성GS-LAK세포，용MTT법측정기대악성뇌효질류세포(BT325)적살상활성，병여LAK세포상비교。결과：효응세포GS-LAK재증식수량화살상악성뇌효질류세포활성등방면균우우LAK세포，차IL-2용량감소。결론：채용GS-LAK세포，가제고효응세포적수량화활성，위악성뇌효질류적면역치료타하료이론기출。
Objective: To investigate a new method for improving the therapeutic effect on malignant glioma. Methods: A new type of killer cells, named GS-LAK, was induced by means of costimulating the peripheral ginsenoside(GS) and interleukin-2 (IL-2). Comparing with control group-LAK cells, cytotoxicity of GS-LAK cells against malignant glioma cells(BT325) was examined with MTI method. Results: It showed that GS-LAK cells exhibited some advantages over LAKcells in proliferation, cytotoxicity, as well as the utilizing of IL-2. Conclusion: The application of GS-LAK cells mightopen a new prospect to clinical therapeutic approach to malignant glioma.