上海医学
上海醫學
상해의학
SHANGHAI MEDICAL JOURNAL
2000年
8期
486-488
,共3页
米非司酮%促宫颈成熟%剂量%足月妊娠
米非司酮%促宮頸成熟%劑量%足月妊娠
미비사동%촉궁경성숙%제량%족월임신
Mifepristone%Cervical riponing%At term
目的 评估口服150 mg米非司酮及300 mg米非司酮在足月妊娠中促宫颈成熟效果及对新生儿的安全性观察。方法 250位宫颈Bishop评分≤5分的初产妇，随机分为三个治疗组，观察其服药前后的宫颈Bishop评分改变及产科结局。结果 150 mg组及300 mg组均具有有效的促宫颈成熟作用，150 mg组胎儿宫内窘迫发生率为12％，合并胎儿宫内窘迫而剖宫产者28．57％(10／35)。300 mg组胎儿宫内窘迫发生率为23％，合并胎儿宫内窘迫而剖宫产者52．63％(20／38)。两组间有显著性差异(P<0．05)。结论 米非司酮为受体水平的抗孕激素，它可软化宫颈、提高子宫的活性。在本研究中150 mg组米非司酮具有有效的促宫颈成熟作用，且胎儿宫内窘迫发生率相对较低。
目的 評估口服150 mg米非司酮及300 mg米非司酮在足月妊娠中促宮頸成熟效果及對新生兒的安全性觀察。方法 250位宮頸Bishop評分≤5分的初產婦，隨機分為三箇治療組，觀察其服藥前後的宮頸Bishop評分改變及產科結跼。結果 150 mg組及300 mg組均具有有效的促宮頸成熟作用，150 mg組胎兒宮內窘迫髮生率為12％，閤併胎兒宮內窘迫而剖宮產者28．57％(10／35)。300 mg組胎兒宮內窘迫髮生率為23％，閤併胎兒宮內窘迫而剖宮產者52．63％(20／38)。兩組間有顯著性差異(P<0．05)。結論 米非司酮為受體水平的抗孕激素，它可軟化宮頸、提高子宮的活性。在本研究中150 mg組米非司酮具有有效的促宮頸成熟作用，且胎兒宮內窘迫髮生率相對較低。
목적 평고구복150 mg미비사동급300 mg미비사동재족월임신중촉궁경성숙효과급대신생인적안전성관찰。방법 250위궁경Bishop평분≤5분적초산부，수궤분위삼개치료조，관찰기복약전후적궁경Bishop평분개변급산과결국。결과 150 mg조급300 mg조균구유유효적촉궁경성숙작용，150 mg조태인궁내군박발생솔위12％，합병태인궁내군박이부궁산자28．57％(10／35)。300 mg조태인궁내군박발생솔위23％，합병태인궁내군박이부궁산자52．63％(20／38)。량조간유현저성차이(P<0．05)。결론 미비사동위수체수평적항잉격소，타가연화궁경、제고자궁적활성。재본연구중150 mg조미비사동구유유효적촉궁경성숙작용，차태인궁내군박발생솔상대교저。
Objectives To compare the effectiveness and safety of 150 mg and 300 mg oral mifepristone on cer-vical ripening of primigravidae. Methods 250 primigravidae at term with a Bishop score of 5 or less were randomly as-signed to one of the three treatment groups, and to observe the alterations in Bishop score after oral Mifepristone andthe outcomes of pregnancy. Results 150 mg and 300 mg oral mifepristone could improve cervical ripening. In thegroup treated with 300 mg mifepristone, the rate of fetal distress was 23% and rate of cesarean section was 52.63%(20/38). While in the group treated with 150 mg mifepristone, the rate of fetal distress was 12 % and rate of cesareansection was 28.57%(10/35). Conclusions Mifepristone, a progesterone antagonist, is known to cause softening anddilation of the early pregnant cervix and increase in uterine activity. In this study, 150 mg of mifepristone improves thecervical ripening and causes lower rate of fetal distress. (Shanghai Med J, 2000,23:486-488)
