CAJ | 학술논문

目的　探讨促性腺激素释放激素激动剂(GnRHa)对子宫肌瘤内雌、孕激素受体(ER、PR)、表皮生长因子受体(EGF-R)的影响。方法　测定13例子宫肌瘤患者经GnRHa治疗3月后肌瘤内雌、孕激素受体和EGF-R水平，并以28例未用药肌瘤作对照。结果　 GnRHa治疗组肌瘤内ER、PR、EGF-R水平明显低于对照组。结论　GnRHa除减少肌瘤内ER、PR外，使肌瘤内EGF-R的水平下降可能是GnRHa治疗子宫肌瘤的一个重要机制。
목적　탐토촉성선격소석방격소격동제(GnRHa)대자궁기류내자、잉격소수체(ER、PR)、표피생장인자수체(EGF-R)적영향。방법　측정13례자궁기류환자경GnRHa치료3월후기류내자、잉격소수체화EGF-R수평，병이28례미용약기류작대조。결과　 GnRHa치료조기류내ER、PR、EGF-R수평명현저우대조조。결론　GnRHa제감소기류내ER、PR외，사기류내EGF-R적수평하강가능시GnRHa치료자궁기류적일개중요궤제。
Objective To study the effect of GnRHa on ER、PR and EGF- R in uterine leiomy-oma. Methods ER、PR and EGF- R in uterine leiomyoma in 13 patients (study group) who hadbeen treated with GnRHa 150μg/d for 3 months before operation were compared with 28 patients (con-trol group) in whom no GnRHa was taken. Results The ER, PR and EGF- R in the GnRHa treat-ed patients were significantly lower than those in the control group. Conclusion In addition to de-creasing the ER and PR content, GnRHa can reduce the EGF- R level in leiomyoma. This may be animportant therapeutic mechanism of GnRHa.