CAJ | 학술논문

目的　观察67-KD层粘连蛋白受体(67-KD laminin receptor，67-KDLN-R)在人喉鳞癌细胞中的表达情况，并分析其表达与临床病理特征间的关系。方法　采用免疫组化SP方法　检测30例喉鳞癌原发灶和其中的3例颈淋巴结转移灶石蜡标本中67-KDLN-R的表达。结果　 67-KDLN-R在喉鳞癌原发灶中的阳性率为56．7％(17／30)。转移淋巴结的免疫反应结果　与原发部位的免疫反应结果　相一致。67-KD LN-R的表达与肿瘤的分化程度密切相关，分化差者其表达水平更高(P<0．05)。与无颈淋巴结转移的喉鳞癌细胞相比，有颈淋巴结转移喉鳞癌细胞67-KDLN-R的表达水平更高(P<0．05)。结论　 67-KDLN-R在喉鳞癌分化、增殖、浸润及转移中起重要作用。
목적　관찰67-KD층점련단백수체(67-KD laminin receptor，67-KDLN-R)재인후린암세포중적표체정황，병분석기표체여림상병리특정간적관계。방법　채용면역조화SP방법　검측30례후린암원발조화기중적3례경림파결전이조석사표본중67-KDLN-R적표체。결과　 67-KDLN-R재후린암원발조중적양성솔위56．7％(17／30)。전이림파결적면역반응결과　여원발부위적면역반응결과　상일치。67-KD LN-R적표체여종류적분화정도밀절상관，분화차자기표체수평경고(P<0．05)。여무경림파결전이적후린암세포상비，유경림파결전이후린암세포67-KDLN-R적표체수평경고(P<0．05)。결론　 67-KDLN-R재후린암분화、증식、침윤급전이중기중요작용。
Objective To observe the expression of 67 - KD laminin receptor (67 - KD LN -R) in human laryngeal squamous carcinoma cells and to analyse the correlation between its expressionand clinicopathological characters. Methods We examined the expression of 67 - KD LN - R in 30primary laryngeal squamous carcinomas and in 3 cervical metastatic lymph nodes by the immunohistoche-mical SP method on paraffin- embedded sections. Results The positive rate of 67 - KD LN - R inthe primary site of laryngeal squamous carcinomas was 56.7 % (17/30). The immunoreactivity in 3 cer-vical metastatic lymph nodes was consistent with that in primary tumors. There was a significant corre-lation between the level of 67 - KD LN - R and the degree of tumor differentiation, the level being high-er in poorly differentiated tumors ( P<0.05). The level of 67 - KD LN - R in laryngeal squamous car-cinomas with cervical lymph node metastases was higher than that in those without cervical lymph nodemetastases ( P <0.05). Conclusion 67 - KD LN - R plays an important role in the differentiation,proliferation, invasiveness and metastasis of laryngeal squamous carcinoma.