CAJ | 학술논문

目的:考察糖原磷酸化酶抑制剂山楂酸对正常和实验性高血糖模型小鼠的降血糖作用及对肝糖原的影响,初步探讨其降糖机制.方法:山楂酸灌胃7天,分别以皮下注射肾上腺素,口服葡萄糖造成小鼠高血糖模型,与正常组一起测定静脉血糖和肝糖原含量.结果:山楂酸可显著对抗肾上腺素、葡萄糖引起的血糖升高,对抗肾上腺素引起的肝糖原降解,增加葡萄糖致高血糖小鼠肝糖原含量;可增加正常小鼠肝糖原储备,但不影响正常血糖.结论:山楂酸具有降血糖作用,机制与其抑制肝糖原分解有关.
목적:고찰당원린산화매억제제산사산대정상화실험성고혈당모형소서적강혈당작용급대간당원적영향,초보탐토기강당궤제.방법:산사산관위7천,분별이피하주사신상선소,구복포도당조성소서고혈당모형,여정상조일기측정정맥혈당화간당원함량.결과:산사산가현저대항신상선소、포도당인기적혈당승고,대항신상선소인기적간당원강해,증가포도당치고혈당소서간당원함량;가증가정상소서간당원저비,단불영향정상혈당.결론:산사산구유강혈당작용,궤제여기억제간당원분해유관.
AIM: To determine the effects of maslinic acid, a novel glycogen phosphorylase inhibitor, on blood glucose and hepatic glycogen in normal and hyperglycemia mice and investigate its mechanism. METHODS: Mice were given intragastrically either vehicle or maslinic acid for 7 days. The model of hyperglycemia in mice was set up by subcutaneous injection of adrenaline or intragastric administration of glucose respectively; the fasting plasma glucose and hepatic glycogen of both normal and hyperglycemia mice were measured. RESULTS: The elevation of blood glucose level caused by adrenaline or glucose was antagonized by maslinic acid significantly. Maslinic acid also increased the hepatic glycogen content in both adrenaline and glucose-induced hyperglycemia mice. Maslinic acid showed no significant effect on fasting plasma glucose level while increased the hepatic glycogen content of normal mice. CONCLUSION: Maslinic acid presents anti-diabetic effect, the mechanism is probably concerned with inhibiting excessive hepatic glycogen degradation.