CAJ | 학술논문

目的:为了观察新生儿与小婴儿巨结肠平滑肌病理改变,方法:对15例新生儿和小婴儿巨结肠手术标本进行病理组织学与抗肌动蛋白免疫组化观察.结果:见平滑肌层网状纤维密度增加、PAS环变形、平滑肌嗜酸性变、肌动蛋白减少或消失等变化由近至远段依次加重、与神经节细胞分布有关.结论:本病肌层病变具有一定特征,对临床有实用价值.
목적:위료관찰신생인여소영인거결장평활기병리개변,방법:대15례신생인화소영인거결장수술표본진행병리조직학여항기동단백면역조화관찰.결과:견평활기층망상섬유밀도증가、PAS배변형、평활기기산성변、기동단백감소혹소실등변화유근지원단의차가중、여신경절세포분포유관.결론:본병기층병변구유일정특정,대림상유실용개치.
Objective:To observe the pathological changes in myenteron of the colon in neonates and infants with Hirschsprung's disease(HD).Methods:The changes of muscular layer in histology and actin immuno-histochemistry were studied in 15 specimens of affected colon obtained during operation.Results:The density of reticular fibers in smooth muscle increased.PAS cycles deformed,the smooth muscles showed acidophilic degeneration and actin decreased or disappeared.All of these changed progressively from the proximal to the distal,and correlated with the distribution of ganglion cells.Conclusion:These characteristic pathological changes in the muscular layer in neonates and infants with HD may be of practical value.