中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2010年
8期
1137-1138
,共2页
刘庆祚%吴吉涛%奉友刚%王琳%门昌平%张鹏%高振利
劉慶祚%吳吉濤%奉友剛%王琳%門昌平%張鵬%高振利
류경조%오길도%봉우강%왕림%문창평%장붕%고진리
膀胱肿瘤%雄激素受体%免疫组织化学
膀胱腫瘤%雄激素受體%免疫組織化學
방광종류%웅격소수체%면역조직화학
Bladder neoplasms%Androgen receptor%Immunohistochemical
目的 观察雄激素受体(AR)在膀胱癌中的表达及其与临床病理特征的关系,探讨其临床意义.方法 采用免疫组织化学SP法检测AR蛋白在123例膀胱尿路上皮癌和18例正常膀胱黏膜中的表达.结果 AR蛋白的阳性表达主要定位于细胞核中,其在膀胱癌组织中阳性表达率为46.3%,在正常膀胱黏膜组织阳性表达率为5.6%,差异有统计学意义(P<0.05).AR的表达率随着膀胱癌病理分级和临床分期的升高而增高(P<0.05),而与年龄和性别无明显相关(P>0.05),有淋巴结转移者AR表达率也显著升高(P<0.05).结论 AR在膀胱癌组织中有广泛表达,且与膀胱癌的分化和浸润性进展密切相关,提示AR蛋白可能在膀胱癌的发生发展中起重要作用.
目的 觀察雄激素受體(AR)在膀胱癌中的錶達及其與臨床病理特徵的關繫,探討其臨床意義.方法 採用免疫組織化學SP法檢測AR蛋白在123例膀胱尿路上皮癌和18例正常膀胱黏膜中的錶達.結果 AR蛋白的暘性錶達主要定位于細胞覈中,其在膀胱癌組織中暘性錶達率為46.3%,在正常膀胱黏膜組織暘性錶達率為5.6%,差異有統計學意義(P<0.05).AR的錶達率隨著膀胱癌病理分級和臨床分期的升高而增高(P<0.05),而與年齡和性彆無明顯相關(P>0.05),有淋巴結轉移者AR錶達率也顯著升高(P<0.05).結論 AR在膀胱癌組織中有廣汎錶達,且與膀胱癌的分化和浸潤性進展密切相關,提示AR蛋白可能在膀胱癌的髮生髮展中起重要作用.
목적 관찰웅격소수체(AR)재방광암중적표체급기여림상병리특정적관계,탐토기림상의의.방법 채용면역조직화학SP법검측AR단백재123례방광뇨로상피암화18례정상방광점막중적표체.결과 AR단백적양성표체주요정위우세포핵중,기재방광암조직중양성표체솔위46.3%,재정상방광점막조직양성표체솔위5.6%,차이유통계학의의(P<0.05).AR적표체솔수착방광암병리분급화림상분기적승고이증고(P<0.05),이여년령화성별무명현상관(P>0.05),유림파결전이자AR표체솔야현저승고(P<0.05).결론 AR재방광암조직중유엄범표체,차여방광암적분화화침윤성진전밀절상관,제시AR단백가능재방광암적발생발전중기중요작용.
Objective To investigate the expression of androgen receptor (AR) in bladder urothelial carcinoma and to explore its clinical significance. Methods Immunohistochemical SP method was employed to detected the expression of AR in bladder cancer tissue (123 cases) and the normal controls (18 cases) . In addition,clinicopathological data of them were analyzed. Results AR protein was mainly localized at cellular nucleus of malignant cells. The positive expression rate of AR in bladder cancer tissue was 46.3% ,but low positive expression rate (5.6% ) was found in normal bladder tissue. The expression of AR was markedly associated with tumor pathological grade and clinical stage ( P < 0.05 ) , but not with age and sex. Moreover,the expression of AR was observed more frequently in cases with lymph node metastasis. Conclusion The expression of AR is associated with differentiation and invasion in bladder urothelial carcinoma, it implies that AR might play important roles in the development and progression of bladder cancer.