中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2011年
6期
498-501
,共4页
丁问微%田英%金军%王英%崔昌%张琳%高宇%王筱金%施蓉
丁問微%田英%金軍%王英%崔昌%張琳%高宇%王篠金%施蓉
정문미%전영%금군%왕영%최창%장림%고우%왕소금%시용
烃类,溴化%乳,人%婴儿,新生%母亲暴露
烴類,溴化%乳,人%嬰兒,新生%母親暴露
경류,추화%유,인%영인,신생%모친폭로
Hydrocarbons,brominatod%Milk,human%Infant,newborn%Maternal exposure
目的 测定上海市某医院产妇乳汁中六溴环十二烷(hexabromocyclododecane,HBCD)含量水平,并估算新生儿每日经母乳HBCD摄人量.方法 于2006年9月至2007年4月在上海市城郊地区某三级甲等医院对分娩后的产妇进行问卷调查,并收集母乳样品48个,产妇均为单胎妊娠,排除高血压、糖尿病、HIV 感染和不良用药史.采用液相色谱-电喷雾离子源-串联三重四极杆质谱法测定α-HBCD,β-HBCD,γ-HBCD 3种非对映异构体的含量,并通过模型估算新生儿经母乳HBCD日摄入量.结果 上海市某医院产妇母乳中总HBCD浓度范围为0.11-37.75 ng/g脂重(lipid weight,1w),中位数为1.42 ng/g 1w,在79%(38/48)的样品中被检出.其中α-HBCD含量最高,浓度中位数为1.24 ng/g 1w,在77%(37/48)的样品中检出;其次为γ-HBCD、β-HBCD,浓度中位数均小于检测限,分别在13%(6/48),17%(7148)的样品中检出.新生儿经母乳总HBCD日摄人为:0.71-243.46 ng/kg.结论 上海市某医院产妇母乳中HBCD含量水平较高,其对婴幼儿健康的影响值得进一步研究.
目的 測定上海市某醫院產婦乳汁中六溴環十二烷(hexabromocyclododecane,HBCD)含量水平,併估算新生兒每日經母乳HBCD攝人量.方法 于2006年9月至2007年4月在上海市城郊地區某三級甲等醫院對分娩後的產婦進行問捲調查,併收集母乳樣品48箇,產婦均為單胎妊娠,排除高血壓、糖尿病、HIV 感染和不良用藥史.採用液相色譜-電噴霧離子源-串聯三重四極桿質譜法測定α-HBCD,β-HBCD,γ-HBCD 3種非對映異構體的含量,併通過模型估算新生兒經母乳HBCD日攝入量.結果 上海市某醫院產婦母乳中總HBCD濃度範圍為0.11-37.75 ng/g脂重(lipid weight,1w),中位數為1.42 ng/g 1w,在79%(38/48)的樣品中被檢齣.其中α-HBCD含量最高,濃度中位數為1.24 ng/g 1w,在77%(37/48)的樣品中檢齣;其次為γ-HBCD、β-HBCD,濃度中位數均小于檢測限,分彆在13%(6/48),17%(7148)的樣品中檢齣.新生兒經母乳總HBCD日攝人為:0.71-243.46 ng/kg.結論 上海市某醫院產婦母乳中HBCD含量水平較高,其對嬰幼兒健康的影響值得進一步研究.
목적 측정상해시모의원산부유즙중륙추배십이완(hexabromocyclododecane,HBCD)함량수평,병고산신생인매일경모유HBCD섭인량.방법 우2006년9월지2007년4월재상해시성교지구모삼급갑등의원대분면후적산부진행문권조사,병수집모유양품48개,산부균위단태임신,배제고혈압、당뇨병、HIV 감염화불량용약사.채용액상색보-전분무리자원-천련삼중사겁간질보법측정α-HBCD,β-HBCD,γ-HBCD 3충비대영이구체적함량,병통과모형고산신생인경모유HBCD일섭입량.결과 상해시모의원산부모유중총HBCD농도범위위0.11-37.75 ng/g지중(lipid weight,1w),중위수위1.42 ng/g 1w,재79%(38/48)적양품중피검출.기중α-HBCD함량최고,농도중위수위1.24 ng/g 1w,재77%(37/48)적양품중검출;기차위γ-HBCD、β-HBCD,농도중위수균소우검측한,분별재13%(6/48),17%(7148)적양품중검출.신생인경모유총HBCD일섭인위:0.71-243.46 ng/kg.결론 상해시모의원산부모유중HBCD함량수평교고,기대영유인건강적영향치득진일보연구.
Objective To explore the level of hexabromocyclododecane(HBCD)in human breast milk of delivery women in a Shanghai hospital.and estimate the daily intake of newborns from breast milk.Methods Forty-eight delivery women in a Shanghai suburb hospital(Class A,Grade 3)were surveyed by questionnaires.and their breast milk samples were collected from September 2006 to April 2007.All the delivery women were singleton pregnancies,excluding high blood pressure,diabetes,HIV infection and adverse medical history.Three diastereoisomers(α-HBCD,β-HBCD,γ-HBCD)were measured by the liquid chromatography-electrospmy ion source-tandem mass spectrometry.and then esitmated the daily intake of the newborns from the breast milk.Results The total HBCD concentration of breast milk,which was detected in 79%(38/48)of samples,ranged from 0.11 ng/g lipid weight(1w)to 37.75 ng/g 1w,with the median at 1.42 ng/g 1w.The most abundant diastereoisomer was α-HBCD which detected in 77%(37/48)of samples,with a median of 1.24,g/g 1w;followed by γ-HBCD and β-HBCD,detected in 13%(6/48)and 17%(8/48)of samples respectively,whose median were both under the limit of detection (LOD).The daily intake of the newborns from the breast milk ranged from 0.71 ng/kg to 243.46 ng/kg.Conclusion The concentrations of HBCD in breast milk of delivery women in a Shanghai hospital have been in a high level.and the influence on newborns'health need to be further studied.
