全科医学临床与教育
全科醫學臨床與教育
전과의학림상여교육
CLINICAL EDUCATION OF GENERAL PRACTICE
2013年
4期
405-407
,共3页
盐酸舍曲林%心理干预%糖尿病%抑郁症
鹽痠捨麯林%心理榦預%糖尿病%抑鬱癥
염산사곡림%심리간예%당뇨병%억욱증
sertraline%psychological intervention%diabetes%depression
目的探讨盐酸舍曲林联合心理干预治疗糖尿病合并抑郁症患者的疗效和安全性。方法将82例糖尿病合并抑郁症患者随机分治疗组和对照组，对照组采用常规降血糖方案治疗，治疗组在对照组基础上加用盐酸舍曲林，同时联合心理干预治疗，共观察6周。两组治疗疗效和不良反应分别采用汉密顿抑郁量表（HAMD）和副反应量表（TESS）评定。结果治疗组的第2周末、第4周末和第6周末HAMD评分与治疗前比较，差异均有统计学意义（t分别=2.69、2.64、2.64，P均＜0.05），而6周末治疗组和对照组HAMD评分比较，差异有统计学意义（t=2.53，P＜0.05）；两组间治愈率和有效率比较，差异均有统计学意义（χ2分别=5.02、4.98，P均＜0.05）；治疗组不良反应发生例数少于对照组，但两组比较，差异无统计学意义（χ2=1.32，P＞0.05）。结论盐酸舍曲林联合心理干预治疗糖尿病合并抑郁症患者疗效确切。
目的探討鹽痠捨麯林聯閤心理榦預治療糖尿病閤併抑鬱癥患者的療效和安全性。方法將82例糖尿病閤併抑鬱癥患者隨機分治療組和對照組，對照組採用常規降血糖方案治療，治療組在對照組基礎上加用鹽痠捨麯林，同時聯閤心理榦預治療，共觀察6週。兩組治療療效和不良反應分彆採用漢密頓抑鬱量錶（HAMD）和副反應量錶（TESS）評定。結果治療組的第2週末、第4週末和第6週末HAMD評分與治療前比較，差異均有統計學意義（t分彆=2.69、2.64、2.64，P均＜0.05），而6週末治療組和對照組HAMD評分比較，差異有統計學意義（t=2.53，P＜0.05）；兩組間治愈率和有效率比較，差異均有統計學意義（χ2分彆=5.02、4.98，P均＜0.05）；治療組不良反應髮生例數少于對照組，但兩組比較，差異無統計學意義（χ2=1.32，P＞0.05）。結論鹽痠捨麯林聯閤心理榦預治療糖尿病閤併抑鬱癥患者療效確切。
목적탐토염산사곡림연합심리간예치료당뇨병합병억욱증환자적료효화안전성。방법장82례당뇨병합병억욱증환자수궤분치료조화대조조，대조조채용상규강혈당방안치료，치료조재대조조기출상가용염산사곡림，동시연합심리간예치료，공관찰6주。량조치료료효화불량반응분별채용한밀돈억욱량표（HAMD）화부반응량표（TESS）평정。결과치료조적제2주말、제4주말화제6주말HAMD평분여치료전비교，차이균유통계학의의（t분별=2.69、2.64、2.64，P균＜0.05），이6주말치료조화대조조HAMD평분비교，차이유통계학의의（t=2.53，P＜0.05）；량조간치유솔화유효솔비교，차이균유통계학의의（χ2분별=5.02、4.98，P균＜0.05）；치료조불량반응발생례수소우대조조，단량조비교，차이무통계학의의（χ2=1.32，P＞0.05）。결론염산사곡림연합심리간예치료당뇨병합병억욱증환자료효학절。
Objective To explore the effect and safety of sertraline combined with psychological intervention in treat-ment of diabetic depression. Methods A total of 82 diabetics with depression were randomly divided into treatment group and control group. The control group was given conventional hypoglycemic therapy while the treatment group was given ser-traline combined with psychological intervention based on the control group treatment. Hamilton Depression scale was used to evaluate the clinical efficacy and treatment emergent symptom scale was used to observe the side effects. Results Com-pared with prior treatment, the diffierences of HAMD score of treatment group at the second, fourth and sixth week were statistic significance(t=2.69,2.64,2.64,P<0.05).Compared with the control group,the HAMD score of treatment group was significantly lower at sixth week (t=2.53, P<0.05). The cure rate and effective rate were significantly different (χ2=5.02,4.98,P<0.05). The adverse reactions of treatment group was less than the control group, but there was no statistic significantly difference(χ2=1.32,P>0.05). Conclusions The effect of sertraline combined with psychological intervention in the treatment of diabetic depression is definite.
