CAJ | 학술논문

目的: 该研究应用加速康复外科新理念,观察对结直肠癌病人手术后炎症反应和免疫功能的影响. 方法:将30例结直肠癌手术病人随机分为两组,研究组(FTS组)病人应用加速康复外科治疗,对照组病人应用传统围手术期处理方法.观察两组病人术后首次肠道通气时间、术后住院时间和并发症,并于术前1天、术后第1天和第3天检测病人外周血清中IL-6、CRP、CD3、CD4、CD8和CD4/CD8比值. 结果: FTS组与对照组比,术后住院时间显著缩短(P<0.05);术后首次排气时间显著提前(P<0.05);而术后并发症两者无显著差异.FTS组与对照组比,术后第1、3天外周血中CRP和IL-6浓度均有显著下降(P<0.05);CD4/CD8比值均有显著增加(P<0.05).结论: 应用加速康复外科能缓解结直肠癌手术病人的术后炎症反应,保护术后细胞免疫功能,促进病人快速康复.
목적: 해연구응용가속강복외과신이념,관찰대결직장암병인수술후염증반응화면역공능적영향. 방법:장30례결직장암수술병인수궤분위량조,연구조(FTS조)병인응용가속강복외과치료,대조조병인응용전통위수술기처리방법.관찰량조병인술후수차장도통기시간、술후주원시간화병발증,병우술전1천、술후제1천화제3천검측병인외주혈청중IL-6、CRP、CD3、CD4、CD8화CD4/CD8비치. 결과: FTS조여대조조비,술후주원시간현저축단(P<0.05);술후수차배기시간현저제전(P<0.05);이술후병발증량자무현저차이.FTS조여대조조비,술후제1、3천외주혈중CRP화IL-6농도균유현저하강(P<0.05);CD4/CD8비치균유현저증가(P<0.05).결론: 응용가속강복외과능완해결직장암수술병인적술후염증반응,보호술후세포면역공능,촉진병인쾌속강복.
Objective: The aim of this study was to evaluate the impact of fast track surgery on host cell-mediated immunology and inflammatory responses in colorectal cancer patients.Methods: Sixty colorectal cancer patients were prospectively divided into fast track surgery(FTS)group(n=30)and conventional perioperative care group(n=30).In addition to clinical parameters(recovery of gastrointestinal function,complication rates and postoperative length of stay), the parameters of perioperative cell-mediated immunology function,and the serum level changes of CRP and IL-6 were determined.Results: FTS group was associated with a significantly shorter postoperative hospital stay compared with conventional care group(P<0.05).Serum concentration of CRP and IL-6 in FTS group were lower(P<0.05) than in the conventional care group on postoperative day(POD) 1 and POD 3(P<0.05).CD4/CD8 ratio in FTS group were higher(P<0.05) than in the conventional care group on postoperative day(POD)1 and POD 3(P<0.05).Conclusion: Fast track surgery for colorectal cancer patients can preserve cell-mediated immunity and control inflammatory responses when compared with conventional postoperative care.