中国抗生素杂志
中國抗生素雜誌
중국항생소잡지
CHINESE JOURNAL OF ANTIBIOTICS
2010年
1期
30-32
,共3页
盐酸吉两他滨%脂质体%包封率%逆相蒸发法
鹽痠吉兩他濱%脂質體%包封率%逆相蒸髮法
염산길량타빈%지질체%포봉솔%역상증발법
Gemcitabine hydrochloride%Liposome%Entrapment efficiency%Reversed-phase evaporation method
采用逆相蒸发法制备盐酸吉西他滨脂质体,建立盐酸吉西他滨脂质体的含量测定和包封率的HPLC方法.所制备的脂质体外观圆整而均匀,平均包封率为81.2%,平均粒径为187.5nm.
採用逆相蒸髮法製備鹽痠吉西他濱脂質體,建立鹽痠吉西他濱脂質體的含量測定和包封率的HPLC方法.所製備的脂質體外觀圓整而均勻,平均包封率為81.2%,平均粒徑為187.5nm.
채용역상증발법제비염산길서타빈지질체,건립염산길서타빈지질체적함량측정화포봉솔적HPLC방법.소제비적지질체외관원정이균균,평균포봉솔위81.2%,평균립경위187.5nm.
Gemcitabine hydrochloride liposome was prepared through a method of Reverse-phase evaporation, and a HPLC method for the determination of the content and entrapment efficiency of gemcitabine hydrochloride liposome was established. It was showed that the prepared gemcitabine hydrochloride liposome was well-distributed with a spherical shape. The average entrapment efficiency of the liposome was 81.2%, and the average size was 187.5 nm.
