国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2012年
5期
480-483
,共4页
维生素D%维生素D受体%肾脏疾病
維生素D%維生素D受體%腎髒疾病
유생소D%유생소D수체%신장질병
Vitamin D%Vitamin D receptor%Kidney disease
维生素D具有广泛的生物学作用,其生物学效应由细胞内特异性的维生素D受体介导.最近研究表明活性维生素D能够减轻肾小球病变和肾小管间质纤维化程度,减少蛋白尿,降低慢性肾脏病患者心血管事件的病死率,对慢性肾病及其并发症有一定疗效.该文就维生素D及其受体在肾脏疾病中作用的研究进展作一综述.
維生素D具有廣汎的生物學作用,其生物學效應由細胞內特異性的維生素D受體介導.最近研究錶明活性維生素D能夠減輕腎小毬病變和腎小管間質纖維化程度,減少蛋白尿,降低慢性腎髒病患者心血管事件的病死率,對慢性腎病及其併髮癥有一定療效.該文就維生素D及其受體在腎髒疾病中作用的研究進展作一綜述.
유생소D구유엄범적생물학작용,기생물학효응유세포내특이성적유생소D수체개도.최근연구표명활성유생소D능구감경신소구병변화신소관간질섬유화정도,감소단백뇨,강저만성신장병환자심혈관사건적병사솔,대만성신병급기병발증유일정료효.해문취유생소D급기수체재신장질병중작용적연구진전작일종술.
Vitamin D is an important hormone.Its biological effect is mediated by intracellular vitamin D receptor-specific.In recent years,studies have shown that active vitamin D and its receptor can reduce the degree of the pathological changes of the glomerular and tubular interstitial fibrosis,decrease 24 hour urinary protein,reduce the mortality rate of cardiovascular diseases,and have protective effect on chronic kidney disease.This paper reviews progress of the vitamin D and its receptor in kidney disease.
