CAJ | 학술논문

在恶性肿瘤侵袭转移的复杂生物学过程中,肿瘤细胞必须适应不同的生存压力.自噬作为一种受诸多基因及其表达产物精细调控的细胞内生理反应,不仅可被激活以适应代谢应激和微环境变化,还可能与肿瘤细胞的上皮-间质转化(EMT)、肿瘤炎症、抵抗失巢凋亡、维持细胞休眠等侵袭转移机制密切相关.
재악성종류침습전이적복잡생물학과정중,종류세포필수괄응불동적생존압력.자서작위일충수제다기인급기표체산물정세조공적세포내생리반응,불부가피격활이괄응대사응격화미배경변화,환가능여종류세포적상피-간질전화(EMT)、종류염증、저항실소조망、유지세포휴면등침습전이궤제밀절상관.
In the complex set of biological processes that a particular malignancy to metastasize,tumor cells must adapt to different survival pressures.As an important cell-physiologic response that under regulation of many genes and their expressions,autophagy not only can be strongly induced to adapt to metabolic stresses and microenvironmental changes,but also involved in the process of epithelial-mesenchymal transition ( EMT),restcting inflammation,resisting anoikis,maintaining dormancy in the metastatic process.