CAJ | 학술논문

胃癌的发病是多因素相互作用的过程,与宿主因素、幽门螺杆菌(Hp)感染、饮食等因素相关.植物多酚是广泛存在于植物中的一大类多酚化合物的总称,具有较强的抗氧化性,许多动物实验和临床研究表明,多酚类物质能够通过抑制Hp感染、抑制核转录因子-κB(NF-κB)表达、促进肿瘤细胞凋亡等多种途径实现对胃癌的抑制.植物多酚的应用拓宽了胃癌化学预防的途径.
위암적발병시다인소상호작용적과정,여숙주인소、유문라간균(Hp)감염、음식등인소상관.식물다분시엄범존재우식물중적일대류다분화합물적총칭,구유교강적항양화성,허다동물실험화림상연구표명,다분류물질능구통과억제Hp감염、억제핵전록인자-κB(NF-κB)표체、촉진종류세포조망등다충도경실현대위암적억제.식물다분적응용탁관료위암화학예방적도경.
Gastric cancer carcinogenesis is a multifactorial process which is related to an interaction of host factors,Helieobacter pylori (Hp) infection,dietary factors and so on.The plant polyphenols which are widely present in many plants are the general term for a large group polyphenolic compounds.They have strong antioxidant activity.Furthermore,many animal experiments and clinical studies have proved that the polyphenols could inhibit gastric cancer via inhibiting Hp infection,suppressing the expression of nuclear factor-κB (NF-κB),promoting apoptosis in cancer cells and so on.The application of plant polyphenols could broaden the approaches for chemoprevention of gastric cancer.