CAJ | 학술논문

目的研究基于CT-MRI融合图像的三维重建技术在颅底外科中的应用.方法采集25例鼻腔鼻窦占位病变患者的鼻窦增强CT及头颅MRI薄层扫描图像数据,使用自行编制的三维重建软件FitMe DICOM viewer 0.15.1对所采集数据进行处理,包括用眼球及枕骨大孔中心点进行CT-MRI的点配准,利用该软件进行融合、分割和三维可视化重建,采用虚拟内镜下观察法、体绘制分割法、自动空间测量法及人工空间测距法对重建后的模型进行操作、观察及测量.结果融合后图像中的重要解剖标志吻合度好.分割的图形边界清晰、完整.重建的结构显示完整、连续、表面光滑.模拟内镜经鼻的观察方式可从鼻腔内部显示颅底各组织的立体结构,三维旋转及透明度调节流畅.体绘制分割后的颅骨残端边界清楚、边缘圆滑,可同时显示骨性标志与颅内软组织模型.测量25例患者肿物模型最大径线自动测量法为(32.007±15.311)mm,人工测量法为(30.240±15.169)mm,差异有统计学意义(t=8.409,P＜0.05).结论利用眼球及枕骨大孔中心点进行点配准的方法可用于头颅CT-MRI图像配准.基于CT-MRI融合图像三维重建出的模型可以准确地反映软组织的大小,通过自动测量法可以更好地进行模型三维测量.重建模型可通过虚拟内镜或体绘制分割来实现由鼻腔内部观察或由外向内观察颅底结构的空间位置关系.将CT-MRI融合图像应用于颅底外科三维重建中,可进行手术人路规划、手术风险评估及空间测量,并为导航图像的立体显示提供参考.
목적 연구기우CT-MRI융합도상적삼유중건기술재로저외과중적응용.방법 채집25례비강비두점위병변환자적비두증강CT급두로MRI박층소묘도상수거,사용자행편제적삼유중건연건FitMe DICOM viewer 0.15.1대소채집수거진행처리,포괄용안구급침골대공중심점진행CT-MRI적점배준,이용해연건진행융합、분할화삼유가시화중건,채용허의내경하관찰법、체회제분할법、자동공간측량법급인공공간측거법대중건후적모형진행조작、관찰급측량.결과 융합후도상중적중요해부표지문합도호.분할적도형변계청석、완정.중건적결구현시완정、련속、표면광활.모의내경경비적관찰방식가종비강내부현시로저각조직적입체결구,삼유선전급투명도조절류창.체회제분할후적로골잔단변계청초、변연원활,가동시현시골성표지여로내연조직모형.측량25례환자종물모형최대경선자동측량법위(32.007±15.311)mm,인공측량법위(30.240±15.169)mm,차이유통계학의의(t=8.409,P＜0.05).결론 이용안구급침골대공중심점진행점배준적방법가용우두로CT-MRI도상배준.기우CT-MRI융합도상삼유중건출적모형가이준학지반영연조직적대소,통과자동측량법가이경호지진행모형삼유측량.중건모형가통과허의내경혹체회제분할래실현유비강내부관찰혹유외향내관찰로저결구적공간위치관계.장CT-MRI융합도상응용우로저외과삼유중건중,가진행수술인로규화、수술풍험평고급공간측량,병위도항도상적입체현시제공삼고.
Objective To study the application of three-dimensional reconstruction technique based on CT-MRI fusion in skull base surgery.Methods To acquire the thin layer CT scan and MRI scanned images,to achieve image registration,fusion,segmentation and 3D visualization by using self-preparation software,to operate,observe and measure models by using methods of endoscopic observation,volume rendering segmentation,automatically and manually measure.Results The center of the eye and foramen magnum in CT-MRI were used as point registration.Good coincidence of important anatomic landmarks were formed in the image fusion.The boundary of spitted graphical was clear and complete.The models showed a complete,continuous,smooth surface. Virtual endoscopy could display the inside three-dimensional structures of skull from nasal with fluent operations of rotation and transparency.The boundary of skull stump segmented after volume rendering segmentation was clear and smooth,and it could show bone signs and soft tissue models together.Cooperation of automatic measurement method [ ( 32.007 ± 15.311 ) mm ] and the manual measurement method [ (30.240 ± 15.169)mm ] for measuring the maximum diameters of the tumor model,the difference was significant ( t =8.409,P ＜ 0.05 ).Conclusions The method of selecting the center of the eye and foramen magnum in point matching is scientific,simple and easy to operate.The models reconstructed based on CT-MRI fusion images can accurately reflect the size of the soft tissue and be better measured through the automatic measurement.Reconstruction models can be observed through the way of virtual endoscopic within the nasal cavity or volume rendering segmentation from outside to inside to frustrate the relationship of skull structures.Three-dimensional reconstruction techniques based on CT-MRI fusion in skull base surgery can be used to plan surgical approach,to assess the risk of surgery and to achieve space measurements,and it laid the foundation for the three-dimensional navigation.