中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2003年
31期
4220-4221
,共2页
应激%记忆%大鼠
應激%記憶%大鼠
응격%기억%대서
目的:研究应激刺激对发育期大鼠空间记忆发育的影响. 方法:采用发育期 Wistar大鼠 22只,按随机抽签法分为应激 1组 (30 V)、应激 2组 (45 V)、对照组.电刺激大鼠 10次 /d,连续 1周;采用血清放免法检测生长激素含量变化;通过 Morris水迷宫检测应激对大鼠空间记忆能力的影响. 结果:应激 2组水迷宫空间学习记忆逃逸时间较应激 1组 [训练第 1～ 5天应激 1, 2组分别为( 23.61± 16.06) ,(14.19± 5.01) s],较对照组 [训练第 1～ 5天为( 26.86± 9.89) s],差异有显著性意义( t=2.35～ 3.02,P< 0.05) ; 应激 2组的生长激素 [(2.24± 0.49) μ g/L]含量偏低 ,应激 1组的生长激素含量 [(3.26± 0.82) μ g/L]有明显增高趋势 (t=2.83,P< 0.05). 结论:应激刺激可提高幼年大鼠空间记忆能力的发育;达到 45 V应激刺激可以影响幼年大鼠的体格发育 ,而 30 V应激刺激则不会妨碍甚至可以促进幼年大鼠的体格发育.
目的:研究應激刺激對髮育期大鼠空間記憶髮育的影響. 方法:採用髮育期 Wistar大鼠 22隻,按隨機抽籤法分為應激 1組 (30 V)、應激 2組 (45 V)、對照組.電刺激大鼠 10次 /d,連續 1週;採用血清放免法檢測生長激素含量變化;通過 Morris水迷宮檢測應激對大鼠空間記憶能力的影響. 結果:應激 2組水迷宮空間學習記憶逃逸時間較應激 1組 [訓練第 1～ 5天應激 1, 2組分彆為( 23.61± 16.06) ,(14.19± 5.01) s],較對照組 [訓練第 1～ 5天為( 26.86± 9.89) s],差異有顯著性意義( t=2.35～ 3.02,P< 0.05) ; 應激 2組的生長激素 [(2.24± 0.49) μ g/L]含量偏低 ,應激 1組的生長激素含量 [(3.26± 0.82) μ g/L]有明顯增高趨勢 (t=2.83,P< 0.05). 結論:應激刺激可提高幼年大鼠空間記憶能力的髮育;達到 45 V應激刺激可以影響幼年大鼠的體格髮育 ,而 30 V應激刺激則不會妨礙甚至可以促進幼年大鼠的體格髮育.
목적:연구응격자격대발육기대서공간기억발육적영향. 방법:채용발육기 Wistar대서 22지,안수궤추첨법분위응격 1조 (30 V)、응격 2조 (45 V)、대조조.전자격대서 10차 /d,련속 1주;채용혈청방면법검측생장격소함량변화;통과 Morris수미궁검측응격대대서공간기억능력적영향. 결과:응격 2조수미궁공간학습기억도일시간교응격 1조 [훈련제 1～ 5천응격 1, 2조분별위( 23.61± 16.06) ,(14.19± 5.01) s],교대조조 [훈련제 1～ 5천위( 26.86± 9.89) s],차이유현저성의의( t=2.35～ 3.02,P< 0.05) ; 응격 2조적생장격소 [(2.24± 0.49) μ g/L]함량편저 ,응격 1조적생장격소함량 [(3.26± 0.82) μ g/L]유명현증고추세 (t=2.83,P< 0.05). 결론:응격자격가제고유년대서공간기억능력적발육;체도 45 V응격자격가이영향유년대서적체격발육 ,이 30 V응격자격칙불회방애심지가이촉진유년대서적체격발육.
AIM: To study the effect of stress on spatial memory development in rats. METHODS: Twenty-two Wistar rats at developmental stage were randomly divided into stress group 1,stress group 2 and control group.The rats in stress groups were subjected to electric stress stimulation at the voltage of 30 V and 40 V 10 times daily for a total of 7 days.The changes of growth hormone(GH) contents in blood serum were measured with the radioimmunoassay.The effect of stress on spatial memory was determined through Morris water maze. RESULTS: The escape time of stress group 2 was apparently shorter than that of the stress group 1[(3.61± 16.06) and (14.19± 5.01) s respectively from the 1 st-5 th day], and was significantly shorter than that of the control group [(6.86± 9.89) s](t=2.35- 3.02, P< 0.01).The concentration of serum GH decreased below the normal range in stress group 2[(2.24± 0.49) μ g/L] while it showed a tendency of apparent increase in stress group 1 [(3.26± 0.82) μ g/L] (t=2.83,P< 0.05). CONCLUSION:Stress can promote the development of spatial memory of the developmental rats.When the voltage is higher than 45 V,stress may be harmful to the physical development of the developmental rats; but when the voltage is 30 V. it doesn't inhibit but even benefit the physical development.
