CAJ | 학술논문

动脉粥样硬化(AS)是一种由免疫介导的、多因素参与的炎症性疾病。流行病学调查显示，在一些自身免疫性疾病中AS有所加剧，例如系统性红斑狼疮(SLE)和抗磷脂综合征。通过研究认为，几个潜在的自身抗原，如氧化低密度脂蛋白、热休克蛋白65/60和β2糖蛋白Ⅰ在AS的发生和发展中发挥着重要作用。这些新的认识，为人们找到了预防和治疗AS的新靶点。
동맥죽양경화(AS)시일충유면역개도적、다인소삼여적염증성질병。류행병학조사현시，재일사자신면역성질병중AS유소가극，례여계통성홍반랑창(SLE)화항린지종합정。통과연구인위，궤개잠재적자신항원，여양화저밀도지단백、열휴극단백65/60화β2당단백Ⅰ재AS적발생화발전중발휘착중요작용。저사신적인식，위인문조도료예방화치료AS적신파점。
Atherosclerosis(AS),a multifactorial inflammatory disease, has been considered as an immtme-mediated process. Immune system has been recognized as an important causitive component of atherosclerotic inflammation. Epidemiological studies demonstrated that atherosclerosis was accelerated in several autoimmune and rheumatic diseases, such as systemic lupus erythematosus(SLE)and antiphospholipid syndrome (APS). Studies showed several potential autoantigens, such as oxLDL, HSP65/60 and β2-GPI, are important in the pathogenesis of atherosclerosis. These studies many contribute to the development of new approaches in the prevention and treatment of atheroaclerosis.