CAJ | 학술논문

目的探讨红细胞平均体积(mean corpuscular volume,MCV)、平均红细胞血红蛋白量(mean corpuscular hemoglobin,MCH)、并结合血红蛋白电泳HbA2检测结果在筛查地中海贫血中的应用价值.方法采用全自动血细胞分析仪分别对200例MCV＜80 fl、MCH＜26 pg实验组和200例MCV＞80 fl、MCH＞26 pg的正常对照者进行血红蛋白电泳测定HbA2,对结果作相关统计学分析,分析MCV、MCH作为地中海贫血筛查方法的敏感度和特异度.结果实验组筛查出地中海贫血的占58.5%,对照者筛查出地中海贫血占2%,实验组MCV、MCH与对照组比较有统计学意义(t=18.214,P＜0.01).结论 MCV、MCH可作为筛查地中海贫血的有效指标,可疑者建议做进一步的检查,以明确诊断.
목적 탐토홍세포평균체적(mean corpuscular volume,MCV)、평균홍세포혈홍단백량(mean corpuscular hemoglobin,MCH)、병결합혈홍단백전영HbA2검측결과재사사지중해빈혈중적응용개치.방법 채용전자동혈세포분석의분별대200례MCV＜80 fl、MCH＜26 pg실험조화200례MCV＞80 fl、MCH＞26 pg적정상대조자진행혈홍단백전영측정HbA2,대결과작상관통계학분석,분석MCV、MCH작위지중해빈혈사사방법적민감도화특이도.결과 실험조사사출지중해빈혈적점58.5%,대조자사사출지중해빈혈점2%,실험조MCV、MCH여대조조비교유통계학의의(t=18.214,P＜0.01).결론 MCV、MCH가작위사사지중해빈혈적유효지표,가의자건의주진일보적검사,이명학진단.
Objective To explore the clinical value of mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),hemoglobinA2(HbA2)'s result in hemoglobin electrophoresis joint detection in the prenatal diagnosis of Thalassemia. Methods MCV and MCH were detected by automatic blood cell analyzer,two hundred samples with MCV ＜ 80fl, MCH ＜ 26pg as experimental group and two hundred samples with MCV ＞ 80fl,MCH ＞ 26pg as control group were tested the HbA2 by hemoglobin electrophoresis. The correlation analysis was performed. To analysis the sensitivity and Specificity of the MCV and MCH as the screening method of the Thalassanemia. Results Of the 200 cases, 58.2% were detected for the Thalassanemia in the experimental group,2% were detected for the Thalassanemia in the control group. There were significant differences between the experimental group and the control group(t = 18. 214, P ＜ 0.01). Conclusion MCV and MCH could screen the Thalassanemia as effective index. Suggestted the suspects should do further examination for explicit diagnosis.