中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
4期
441-442
,共2页
镇痛药%维拉帕米%疼痛测定
鎮痛藥%維拉帕米%疼痛測定
진통약%유랍파미%동통측정
Analgesics%Verapamil%Pain measurement
目的 研究钙拮抗药维拉帕米(Ver)对布桂嗪(AP237)镇痛作用的影响.方法 应用热诱发小鼠疼痛反应模型和冰醋酸诱导小鼠扭体反应模型观察Ver合用AP237对疼痛的抑制作用.结果 低剂量Ver合用AP237(40 mg/kg,80 mg/kg)可明显提高小鼠诱发疼痛反应的痛阈值,推迟小鼠疼痛出现的时间(与单用AP237比较,P<0.05,与对照组比较,P<0.01);低剂量Ver合用AP237(20 mg/kg,40 mg/kg)对小鼠扭体反应次数有明显的抑制作用(与单用AF237比较,P<0.05;与单用AP237比较,P<0.01).结论 Ver可增强AP237的镇痛作用.
目的 研究鈣拮抗藥維拉帕米(Ver)對佈桂嗪(AP237)鎮痛作用的影響.方法 應用熱誘髮小鼠疼痛反應模型和冰醋痠誘導小鼠扭體反應模型觀察Ver閤用AP237對疼痛的抑製作用.結果 低劑量Ver閤用AP237(40 mg/kg,80 mg/kg)可明顯提高小鼠誘髮疼痛反應的痛閾值,推遲小鼠疼痛齣現的時間(與單用AP237比較,P<0.05,與對照組比較,P<0.01);低劑量Ver閤用AP237(20 mg/kg,40 mg/kg)對小鼠扭體反應次數有明顯的抑製作用(與單用AF237比較,P<0.05;與單用AP237比較,P<0.01).結論 Ver可增彊AP237的鎮痛作用.
목적 연구개길항약유랍파미(Ver)대포계진(AP237)진통작용적영향.방법 응용열유발소서동통반응모형화빙작산유도소서뉴체반응모형관찰Ver합용AP237대동통적억제작용.결과 저제량Ver합용AP237(40 mg/kg,80 mg/kg)가명현제고소서유발동통반응적통역치,추지소서동통출현적시간(여단용AP237비교,P<0.05,여대조조비교,P<0.01);저제량Ver합용AP237(20 mg/kg,40 mg/kg)대소서뉴체반응차수유명현적억제작용(여단용AF237비교,P<0.05;여단용AP237비교,P<0.01).결론 Ver가증강AP237적진통작용.
Objective To study the analgesic effects of combination of fortanodyn and verapamil. Methods Used the model of the acetic acid induction writhing in mice and the method of hot-plate in mice, then observe the action of the mice after treatment with combination of fortanodyn and verapamil. Results Low dose Verapamil com-bined AP237 (40 mg/kg, 80 mg/kg)could enhance the threshold of pain of the mouse ache response obviously, and postponed the time which the mouse ache appeared (comparing using simply AP237 P <0.05 with controlled group P <0. 01) ;Low dose Verapamil combined AP237 (20 mg/kg,40 mg/kg) had the obvious inhibitory action in the body turning times of the mouse. Conclusion Verapamil can strengthen the analgesia function of AP237.
