中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2009年
8期
678-682
,共5页
郑茵%云美玲%曾渝%张勇%金水晶%王镇%周代锋%王利%蔡望伟%刘裕芬%吴恳%徐波
鄭茵%雲美玲%曾渝%張勇%金水晶%王鎮%週代鋒%王利%蔡望偉%劉裕芬%吳懇%徐波
정인%운미령%증투%장용%금수정%왕진%주대봉%왕리%채망위%류유분%오간%서파
肽基二肽酶A%基因表达%高血压%动脉硬化
肽基二肽酶A%基因錶達%高血壓%動脈硬化
태기이태매A%기인표체%고혈압%동맥경화
Pentidyl-dipeptidase A%Gene expression%Hypertension%Atherosclerosis
目的 探讨海南黎族人群血管紧张素转换酶(ACE)基因多态性与高血压并动脉硬化的相关性.方法 采用聚合酶链反应(PCR)检测260例海南黎族动脉硬化患者组及276例黎族健康人对照组的ACE基因插入或缺失(I/D)多态性,观察DD、DI、Ⅱ基因型频率及等位基因频率.用高分辨超声技术分别检测DD、DI、Ⅱ 3个亚组的平均颈动脉内-中膜厚度(MIMT). 结果 (1)动脉硬化组DD、DI、Ⅱ基因型频率为15.0%、37.3%、47.7 ;D及Ⅰ等位基因频率分别为33.7%及66.3%.对照组DD、DI、Ⅱ基因型频率17.8%、40.6%、41.7%,D及Ⅰ等位基因频率分别为38.0%及62.0%.两组间DD、DI、Ⅱ基因型频率及D、Ⅰ等位基因频率差异无统计学意义(P>0.05).(2)动脉硬化组在年龄、总胆固醇(TC)、三酰甘油(TG)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、收缩压、舒张压显著高于对照组(P<0.05),而高密度脂蛋白胆固醇(HDL-C)显著低于对照组(P<0.05);Logistic回归分析结果 显示,TG(OR=2.14)、apoA(OR=360.39)、收缩压(OR=1.21)、舒张压(OR=1.08)、ACE DD基因型(OR=0.30)与高血压并动脉硬化相关(P<0.05).ACE DD型亚组的MIMT比DI和Ⅱ型亚组显著增高(P<0.05). 结论 ACE DD基因型增加了颈动脉硬化易感性,是海南黎族高血压并动脉硬化患者的危险因素,可作为动脉粥样硬化的一个早期预测因子.
目的 探討海南黎族人群血管緊張素轉換酶(ACE)基因多態性與高血壓併動脈硬化的相關性.方法 採用聚閤酶鏈反應(PCR)檢測260例海南黎族動脈硬化患者組及276例黎族健康人對照組的ACE基因插入或缺失(I/D)多態性,觀察DD、DI、Ⅱ基因型頻率及等位基因頻率.用高分辨超聲技術分彆檢測DD、DI、Ⅱ 3箇亞組的平均頸動脈內-中膜厚度(MIMT). 結果 (1)動脈硬化組DD、DI、Ⅱ基因型頻率為15.0%、37.3%、47.7 ;D及Ⅰ等位基因頻率分彆為33.7%及66.3%.對照組DD、DI、Ⅱ基因型頻率17.8%、40.6%、41.7%,D及Ⅰ等位基因頻率分彆為38.0%及62.0%.兩組間DD、DI、Ⅱ基因型頻率及D、Ⅰ等位基因頻率差異無統計學意義(P>0.05).(2)動脈硬化組在年齡、總膽固醇(TC)、三酰甘油(TG)、載脂蛋白A(apoA)、載脂蛋白B(apoB)、收縮壓、舒張壓顯著高于對照組(P<0.05),而高密度脂蛋白膽固醇(HDL-C)顯著低于對照組(P<0.05);Logistic迴歸分析結果 顯示,TG(OR=2.14)、apoA(OR=360.39)、收縮壓(OR=1.21)、舒張壓(OR=1.08)、ACE DD基因型(OR=0.30)與高血壓併動脈硬化相關(P<0.05).ACE DD型亞組的MIMT比DI和Ⅱ型亞組顯著增高(P<0.05). 結論 ACE DD基因型增加瞭頸動脈硬化易感性,是海南黎族高血壓併動脈硬化患者的危險因素,可作為動脈粥樣硬化的一箇早期預測因子.
목적 탐토해남려족인군혈관긴장소전환매(ACE)기인다태성여고혈압병동맥경화적상관성.방법 채용취합매련반응(PCR)검측260례해남려족동맥경화환자조급276례려족건강인대조조적ACE기인삽입혹결실(I/D)다태성,관찰DD、DI、Ⅱ기인형빈솔급등위기인빈솔.용고분변초성기술분별검측DD、DI、Ⅱ 3개아조적평균경동맥내-중막후도(MIMT). 결과 (1)동맥경화조DD、DI、Ⅱ기인형빈솔위15.0%、37.3%、47.7 ;D급Ⅰ등위기인빈솔분별위33.7%급66.3%.대조조DD、DI、Ⅱ기인형빈솔17.8%、40.6%、41.7%,D급Ⅰ등위기인빈솔분별위38.0%급62.0%.량조간DD、DI、Ⅱ기인형빈솔급D、Ⅰ등위기인빈솔차이무통계학의의(P>0.05).(2)동맥경화조재년령、총담고순(TC)、삼선감유(TG)、재지단백A(apoA)、재지단백B(apoB)、수축압、서장압현저고우대조조(P<0.05),이고밀도지단백담고순(HDL-C)현저저우대조조(P<0.05);Logistic회귀분석결과 현시,TG(OR=2.14)、apoA(OR=360.39)、수축압(OR=1.21)、서장압(OR=1.08)、ACE DD기인형(OR=0.30)여고혈압병동맥경화상관(P<0.05).ACE DD형아조적MIMT비DI화Ⅱ형아조현저증고(P<0.05). 결론 ACE DD기인형증가료경동맥경화역감성,시해남려족고혈압병동맥경화환자적위험인소,가작위동맥죽양경화적일개조기예측인자.
Objective To explore the correlation between angiotensin converting enzyme (ACE) gene polymorphism and hypertension accompanying atherosclerosis in Li people in Hainan province. Methods Two hundred and sixty patients with hypertension accompanying atherosclerosis were selected as hypertension plus atherosclerosis group, while two hundred and seventy-six healthy people were regarded as healthy control group. ACE I/D gene polymorphism was detected by polymerase chain reaction (PCR), and the genotype frequencies and allele frequencies of DD, DI and Ⅱ were investigated. The carotid intimal-medial thickness(IMT)was measured by high-resolution ultrasound technique and mean IMT (MIMT) was calculated. Results (1) In the hypertension plus atherosclerosis group, the genotype frequencies of DD, DI and Ⅱ were 15.0%, 37.3%, 47.7%,respectively, and the allele frequencies of D and I were 33.70% and 66.30%, respectively. In the healthy control group, the genotype frequencies of DD, DI and Ⅱ were 17.8% , 40.6% and 41.7%,respectively, and the allele frequencies of D and I were 38.0% and 62.0%, respectively. There were no significant differences both in the genotype frequencies of DD, DI and Ⅱ, and in allele frequencies of D and I between the two groups (P>0. 05). (2) The age,total serum cholesterol(TC),triglyceride (TG), systolic pressure(SBP), diastolic pressure(DBP), apolipoprotein A(apoA) and apolipoprotein B (apoB) levels were significantly higher in the hypertension plus atherosclerosis group than in the control group(P<0. 05). The high density lipoprotein cholesterol(HDL-C) level was significantly lower in the hypertension plus atherosclerosis group than in the control group(P<0. 05). Logistic regression analysis showed that TG (OR = 2.14), apoA(OR = 360. 39), SBP(OR = 1.21), DBP (OR=1.08) and ACE DD genetype (OR = 0. 30) had correlation with hypertension plus atherosclerosis(all P<0. 05). The MIMT level was significantly higher in ACE DD subset than in DI and Ⅱ subset (P<0.05). Conclusions The ACE DD genotype increases the susceptibility of carotid atheroselerosis, which is the risk factor for hypertension accompanying atherosclerosis in Li people in Hainan province. It may be an early predictive factor in atherosclerosis.
