CAJ | 학술논문

目的了解山西省某县艾滋病患者中Ⅰ型和Ⅱ型单纯疱疹病毒(HSV-1,HSV-2)的感染率,并分别分析其影响因素.方法对山西某县全部已纳入抗病毒治疗的195例艾滋病患者进行问卷调查.同时血清学检测确定其HSV-1和HSV-2的感染情况;利用单因素logistic回归模型分析数据.结果共收回有效问卷195份,采集血样195份.195例艾滋病患者中,绝大多数(96.9%)为农民;男性116例(59.5%),女性79例(40.5%);年龄以20～50岁为主(146例,占74.9%);已婚有配偶者180例(92.3%).经有偿采供血或输血途径感染者176例,占90.3%.CD4+:T细胞计数(1～1531)×106个/L[(323.6±14.8)×106个/L],26.5%患者的血液CD4+T细胞计数<200×106个/L.154例患者(79.0%)目前有性伴;118例(86.8%)患者最近6个月内每次性行为均使用安全套,123例(91.8%)患者在最近一次的性行为中使用了安全套.HSV-1的IgG抗体阳性率为84.1%(164/195);HSV-2的IgG抗体阳性率为13.3%(26/195).合并感染HSV-1和HSV-2的有14例(7.2%).单因素logistic回归分析显示HSV-2感染与婚姻状况有关(OR=7.41;95%CI:2.42～22.73;P<0.01),未婚患者HSV-2感染率(46.7%,7/15)高于已婚者(10.6%,19/180).结论当地艾滋病患者中存在一定比例的HSV-1和HSV-2感染者.艾滋病患者的HSV-2感染与婚姻状态有关.
목적 료해산서성모현애자병환자중Ⅰ형화Ⅱ형단순포진병독(HSV-1,HSV-2)적감염솔,병분별분석기영향인소.방법 대산서모현전부이납입항병독치료적195례애자병환자진행문권조사.동시혈청학검측학정기HSV-1화HSV-2적감염정황;이용단인소logistic회귀모형분석수거.결과 공수회유효문권195빈,채집혈양195빈.195례애자병환자중,절대다수(96.9%)위농민;남성116례(59.5%),녀성79례(40.5%);년령이20～50세위주(146례,점74.9%);이혼유배우자180례(92.3%).경유상채공혈혹수혈도경감염자176례,점90.3%.CD4+:T세포계수(1～1531)×106개/L[(323.6±14.8)×106개/L],26.5%환자적혈액CD4+T세포계수<200×106개/L.154례환자(79.0%)목전유성반;118례(86.8%)환자최근6개월내매차성행위균사용안전투,123례(91.8%)환자재최근일차적성행위중사용료안전투.HSV-1적IgG항체양성솔위84.1%(164/195);HSV-2적IgG항체양성솔위13.3%(26/195).합병감염HSV-1화HSV-2적유14례(7.2%).단인소logistic회귀분석현시HSV-2감염여혼인상황유관(OR=7.41;95%CI:2.42～22.73;P<0.01),미혼환자HSV-2감염솔(46.7%,7/15)고우이혼자(10.6%,19/180).결론 당지애자병환자중존재일정비례적HSV-1화HSV-2감염자.애자병환자적HSV-2감염여혼인상태유관.
Objective To determine the prevalence of herpes simplex virus(HSV)and its correlates among HIV/AIDS patients in a county of Shanxi.Methods All HIV-infected patients in a county in Shanxi province who were receiving antiretroviral treatment(ART) were included in this study.Participants were interviewed using standard questionnaires.Serum samples were tested to determine HSV-1 and HSV-2 infections.Results A total of 195 AIDS patients were recruited and 195 blood samples were collected.Among 195 AIDS patients.189(96.9%)were farmers;116(59.5%)were men while 79 were women:146(74.9%)were between 20-50 years old:180(92.3%)were married.The maior routes of HIV transmission were blood/plasma donation or transfusion(176 patients,90.3%).CD4+ T cell counts were between(1-1531)×106 cells/L((323.6±14.8)×106 cells/L),with 44(26.5%)patients' CD4+ T cell counts less than 200×106 cells,/L Of which,154 patients(79.0%)had sexual partners.86.8% (118 patients)consistently used condoms during the past 6 months,while for the last sexual act,91.8% (123 patients)used condoms.For anti-HSV-1 status,there were about 164 patients(84.1%)were positive,and 26(13.3%)were positive for anti-HSV-2.While,14(7.2%)were positive for both anti-HSV-1 and anti-HSV-2. Logistic regression analysis indicated that marital status were correlated with HSV-2 infection ( OR = 7.41 ; 95% CI: 2. 42 - 22. 73 ; P < 0. 01 ). No socio-demographic and sexual characteristics were identified to be correlated with HSV-1 infection. Conclusion A substantial proportion of AIDS patients in a rural county of Shanxi province of China were co-infected with HSV-1 and/or HSV-2. Marital status was correlated with HSV-2 infection.