CAJ | 학술논문

目的：探讨Ⅲ、Ⅳ期神经母细胞瘤术前强化疗配合外科手术治疗效果及预后关系。方法：24例手术病例(其中Ⅲ期11例、Ⅳ期13例)，完全切除肿瘤17例，术前均经过化疗3～4疗程，动态观察肿瘤平均缩小率为13．3％～94．0％。结果：平均生存期21个月，其中4例无瘤生存3～4年。结论：应用强化疗后延期手术，对Ⅲ期病例的完整切除，Ⅳ期病例切除原发灶，降低手术并发症，提高生存率有重要意义。
목적：탐토Ⅲ、Ⅳ기신경모세포류술전강화료배합외과수술치료효과급예후관계。방법：24례수술병례(기중Ⅲ기11례、Ⅳ기13례)，완전절제종류17례，술전균경과화료3～4료정，동태관찰종류평균축소솔위13．3％～94．0％。결과：평균생존기21개월，기중4례무류생존3～4년。결론：응용강화료후연기수술，대Ⅲ기병례적완정절제，Ⅳ기병례절제원발조，강저수술병발증，제고생존솔유중요의의。
Objective:To study the correlation between preoperative intensive chemotherapy,surgical operation and the prognosis in stage Ⅲ,Ⅳ neuroblastomas.Methods:Twenty-four cases of neuroblastomas received surgical operatio(11 cases of stage Ⅲ 13 of stage Ⅳ).Seventeen cases had their tumor completely resected had a preoperative chemotherapy for 3～4 cycles.The mean tumor shrinkage rate was 13.3%～94%.Results:The mean survival term was 21 months and 4 of them had tumorfree interval for 3～4 years.Conclusion:It is important that the preoperative intensive chemotherapy is beneficial to the completely resected stage Ⅲ tumor and the stage Ⅳ tumor had their primary focus removed.This treatment can reduce the postoperative complications and increase the patient's survival rate.