CAJ | 학술논문

针对人类疾病基因的精细定位,本文利用稠密的标记位点,通过比较标记的熵和条件熵,给出了一个基于熵的指数.该指数可以度量标记基因和性状位点间连锁不平衡(LD)程度.该指数的特性是它不依赖于标记基因的频率.同时它对应疾病易感位点(DSL)精细定位的哈迪-温伯格不平衡(HWD)指数.通过计算机模拟,文章调查了不同遗传参数下该指数的性质.模拟结果表明该指数用作疾病易感位点精细定位是有效的.
침대인류질병기인적정세정위,본문이용주밀적표기위점,통과비교표기적적화조건적,급출료일개기우적적지수.해지수가이도량표기기인화성상위점간련쇄불평형(LD)정도.해지수적특성시타불의뢰우표기기인적빈솔.동시타대응질병역감위점(DSL)정세정위적합적-온백격불평형(HWD)지수.통과계산궤모의,문장조사료불동유전삼수하해지수적성질.모의결과표명해지수용작질병역감위점정세정위시유효적.
By comparing the entropy and the conditional entropy in a marker,an entropy-based index has been presented for fine-scale linkage disequilibrium gene mapping using high-density marker maps for human disease genes.The index can quantify the level of linkage disequilibrium(LD)between the marker and the disease susceptibility locus(DSL)of genes.The advantage of using the index is attributed to the fact that it does not depend on marker allele frequencies across loci.Moreover,it is parallel to Hardy-Weinberg disequilibrium(HWD)measure for DSL fine mapping.Through various simulations,the fine mapping performances of the proposed entropy-based index was extensively investigated under various genetic parameters.The results show that the index presented is both robust and powerful for DSL mapping in genes.