CAJ | 학술논문

目的观察成年家猪在诱导窒息性心跳骤停过程中心脏节律变化特点.方法对16头成年家猪在呼气末夹闭气管,直至动脉搏动压消失,造成窒息性心跳骤停模型后,再延长窒息8 min,随即开始常规心肺复苏(cardiopulmonary resuscitation,CPR).CPR 3 min后给予肾上腺素0.045 mg/kg静脉注射.复苏20 min内恢复自主循环(restoration of spontaneous circulation,ROSC)的家猪定义为CPR成功,反之界定为死亡.记录各动物从窒息前到CPR开始即刻的心电图.结果达到心跳骤停标准的即刻,16头家猪中2头心电图表现为心室颤动(ventricular fibrillation,VF),4头表现为全心停搏(asys-tole),其余10头呈现无脉性电活动(pulseless electrical activity,PEA).在施行CPR前的8 min非干预时间内,原呈现PEA的10头猪中7头转变成VF.施行CPR的即刻,9头猪表现为VF,3头表现为PEA,4头表现为全心停搏.结论绝大多数成年家猪在诱导窒息性心跳骤停过程中发生PEA,但在延长窒息时间后PEA绝大多数转变为vF.
목적 관찰성년가저재유도질식성심도취정과정중심장절률변화특점.방법 대16두성년가저재호기말협폐기관,직지동맥박동압소실,조성질식성심도취정모형후,재연장질식8 min,수즉개시상규심폐복소(cardiopulmonary resuscitation,CPR).CPR 3 min후급여신상선소0.045 mg/kg정맥주사.복소20 min내회복자주순배(restoration of spontaneous circulation,ROSC)적가저정의위CPR성공,반지계정위사망.기록각동물종질식전도CPR개시즉각적심전도.결과 체도심도취정표준적즉각,16두가저중2두심전도표현위심실전동(ventricular fibrillation,VF),4두표현위전심정박(asys-tole),기여10두정현무맥성전활동(pulseless electrical activity,PEA).재시행CPR전적8 min비간예시간내,원정현PEA적10두저중7두전변성VF.시행CPR적즉각,9두저표현위VF,3두표현위PEA,4두표현위전심정박.결론 절대다수성년가저재유도질식성심도취정과정중발생PEA,단재연장질식시간후PEA절대다수전변위vF.
Objective To observe the changes of cardiac rhythms in a swine model of adult asphyxia! cardiac arrest. Method Sixteen Pigs were aphyxiated by endotracheal tube clamping until 8 min after loss of aortic pulsations. Resuscitation was then provided and swinds were assigned to received 0.045 mg/kg epinephrine intravenously after 3 min of basic life support. The animals with restoration of spontaneous circulation within 20 min from CPR were defined as successfully resuscitated, while the rest were identified as unresuscitation. Electrocardiogram ( EGG) were monitored from the start of asphyxia to the start of the CPR. Results When loss of pulsations occurred, 2 of 16 animals had ventricular fibrillation; 10 pigs exhibited pulseless electrical activity, and 4 pigs had asystole. During the 8 min after the loss of aortic pulsations, pulseless electrical activity converted to VF in 7 pigs. Immidiatedly prior to resuscitation, VF occurred in 9 pigs, asystole in 4 pigs, and PEA in 3 pigs. Conclusions Most of animals in this swine model of asphyxial cardiac arrest presented PEA, but most of them converted to VF especially late in the asphyxial process.